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The generation of cellular diversity in the cerebral cortex

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The generation of cellular diversity in the cerebral cortex. / Price, J; Williams, B P; Götz, M.

In: Ciba Foundation Symposium, Vol. 193, 1995, p. 71-84; discussion 117-26.

Research output: Contribution to journalArticle

Harvard

Price, J, Williams, BP & Götz, M 1995, 'The generation of cellular diversity in the cerebral cortex', Ciba Foundation Symposium, vol. 193, pp. 71-84; discussion 117-26.

APA

Price, J., Williams, B. P., & Götz, M. (1995). The generation of cellular diversity in the cerebral cortex. Ciba Foundation Symposium, 193, 71-84; discussion 117-26.

Vancouver

Price J, Williams BP, Götz M. The generation of cellular diversity in the cerebral cortex. Ciba Foundation Symposium. 1995;193:71-84; discussion 117-26.

Author

Price, J ; Williams, B P ; Götz, M. / The generation of cellular diversity in the cerebral cortex. In: Ciba Foundation Symposium. 1995 ; Vol. 193. pp. 71-84; discussion 117-26.

Bibtex Download

@article{3a3121a8c5b141a8ba9d39895d7e5a3d,
title = "The generation of cellular diversity in the cerebral cortex",
abstract = "We have used retroviral vectors to study cell lineage in the embryonic rat cerebral cortex both in vivo and in dissociated cell culture. We provide evidence that during the late phase of corticogenesis, most precursor cells of the ventricular zone are specified for the production of a single cell type, either neurons or one of the glial cell types. Although specified, the precursor cells that generate neurons can apparently generate both pyramidal and non-pyramidal cells. Earlier stages of development are dominated by a different type of precursor cell with a number of properties that lead us to believe that it is the founding, multipotential precursor cell of the cerebral cortex. We discuss a possible model of cell lineage which unifies these various observations.",
author = "J Price and Williams, {B P} and M G{\"o}tz",
year = "1995",
language = "English",
volume = "193",
pages = "71--84; discussion 117--26",
journal = "Ciba Foundation Symposium",
issn = "0300-5208",
publisher = "Wiley Subscription Services",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The generation of cellular diversity in the cerebral cortex

AU - Price, J

AU - Williams, B P

AU - Götz, M

PY - 1995

Y1 - 1995

N2 - We have used retroviral vectors to study cell lineage in the embryonic rat cerebral cortex both in vivo and in dissociated cell culture. We provide evidence that during the late phase of corticogenesis, most precursor cells of the ventricular zone are specified for the production of a single cell type, either neurons or one of the glial cell types. Although specified, the precursor cells that generate neurons can apparently generate both pyramidal and non-pyramidal cells. Earlier stages of development are dominated by a different type of precursor cell with a number of properties that lead us to believe that it is the founding, multipotential precursor cell of the cerebral cortex. We discuss a possible model of cell lineage which unifies these various observations.

AB - We have used retroviral vectors to study cell lineage in the embryonic rat cerebral cortex both in vivo and in dissociated cell culture. We provide evidence that during the late phase of corticogenesis, most precursor cells of the ventricular zone are specified for the production of a single cell type, either neurons or one of the glial cell types. Although specified, the precursor cells that generate neurons can apparently generate both pyramidal and non-pyramidal cells. Earlier stages of development are dominated by a different type of precursor cell with a number of properties that lead us to believe that it is the founding, multipotential precursor cell of the cerebral cortex. We discuss a possible model of cell lineage which unifies these various observations.

M3 - Article

C2 - 8727487

VL - 193

SP - 71-84; discussion 117-26

JO - Ciba Foundation Symposium

JF - Ciba Foundation Symposium

SN - 0300-5208

ER -

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