The generation of granule cells during the development and evolution of the cerebellum

Angelo Iulianella; Richard J. Wingate; Cecilia B. Moens; Emily Capaldo

doi:10.1002/dvdy.64

The generation of granule cells during the development and evolution of the cerebellum

Angelo Iulianella^*, Richard J. Wingate, Cecilia B. Moens, Emily Capaldo

^*Corresponding author for this work

Developmental Neurobiology

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

The cerebellum coordinates vestibular input into the hindbrain to control balance and movement, and its anatomical complexity is increasingly viewed as a high-throughput processing center for sensory and cognitive functions. Cerebellum development however is relatively simple, and arises from a specialized structure in the anterior hindbrain called the rhombic lip, which along with the ventricular zone of the rostral-most dorsal hindbrain region, give rise to the distinct cell types that constitute the cerebellum. Granule cells, being the most numerous cell types, arise from the rhombic lip and form a dense and distinct layer of the cerebellar cortex. In this short review, we describe the various strategies used by amniotes and anamniotes to generate and diversify granule cell types during cerebellar development.

Original language	English
Pages (from-to)	506-513
Number of pages	8
Journal	Developmental Dynamics
Volume	248
Issue number	7
DOIs	https://doi.org/10.1002/dvdy.64
Publication status	Published - 1 Jul 2019

Keywords

amniotes
anamniotes
Atoh1
cerebellum
Cux2
external granular layer
granule cells

Access to Document

10.1002/dvdy.64

Cite this

@article{441c79ccceba4089a35b2e0624ae07bb,

title = "The generation of granule cells during the development and evolution of the cerebellum",

abstract = "The cerebellum coordinates vestibular input into the hindbrain to control balance and movement, and its anatomical complexity is increasingly viewed as a high-throughput processing center for sensory and cognitive functions. Cerebellum development however is relatively simple, and arises from a specialized structure in the anterior hindbrain called the rhombic lip, which along with the ventricular zone of the rostral-most dorsal hindbrain region, give rise to the distinct cell types that constitute the cerebellum. Granule cells, being the most numerous cell types, arise from the rhombic lip and form a dense and distinct layer of the cerebellar cortex. In this short review, we describe the various strategies used by amniotes and anamniotes to generate and diversify granule cell types during cerebellar development.",

keywords = "amniotes, anamniotes, Atoh1, cerebellum, Cux2, external granular layer, granule cells",

author = "Angelo Iulianella and Wingate, {Richard J.} and Moens, {Cecilia B.} and Emily Capaldo",

year = "2019",

month = jul,

day = "1",

doi = "10.1002/dvdy.64",

language = "English",

volume = "248",

pages = "506--513",

journal = "Developmental Dynamics",

issn = "1058-8388",

publisher = "Wiley-Liss Inc.",

number = "7",

}

TY - JOUR

T1 - The generation of granule cells during the development and evolution of the cerebellum

AU - Iulianella, Angelo

AU - Wingate, Richard J.

AU - Moens, Cecilia B.

AU - Capaldo, Emily

PY - 2019/7/1

Y1 - 2019/7/1

N2 - The cerebellum coordinates vestibular input into the hindbrain to control balance and movement, and its anatomical complexity is increasingly viewed as a high-throughput processing center for sensory and cognitive functions. Cerebellum development however is relatively simple, and arises from a specialized structure in the anterior hindbrain called the rhombic lip, which along with the ventricular zone of the rostral-most dorsal hindbrain region, give rise to the distinct cell types that constitute the cerebellum. Granule cells, being the most numerous cell types, arise from the rhombic lip and form a dense and distinct layer of the cerebellar cortex. In this short review, we describe the various strategies used by amniotes and anamniotes to generate and diversify granule cell types during cerebellar development.

AB - The cerebellum coordinates vestibular input into the hindbrain to control balance and movement, and its anatomical complexity is increasingly viewed as a high-throughput processing center for sensory and cognitive functions. Cerebellum development however is relatively simple, and arises from a specialized structure in the anterior hindbrain called the rhombic lip, which along with the ventricular zone of the rostral-most dorsal hindbrain region, give rise to the distinct cell types that constitute the cerebellum. Granule cells, being the most numerous cell types, arise from the rhombic lip and form a dense and distinct layer of the cerebellar cortex. In this short review, we describe the various strategies used by amniotes and anamniotes to generate and diversify granule cell types during cerebellar development.

KW - amniotes

KW - anamniotes

KW - Atoh1

KW - cerebellum

KW - Cux2

KW - external granular layer

KW - granule cells

UR - http://www.scopus.com/inward/record.url?scp=85067338387&partnerID=8YFLogxK

U2 - 10.1002/dvdy.64

DO - 10.1002/dvdy.64

M3 - Review article

C2 - 31131952

AN - SCOPUS:85067338387

SN - 1058-8388

VL - 248

SP - 506

EP - 513

JO - Developmental Dynamics

JF - Developmental Dynamics

IS - 7

ER -

The generation of granule cells during the development and evolution of the cerebellum

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this