King's College London

Research portal

The genetic architecture of the human cerebral cortex

Research output: Contribution to journalArticle

Standard

The genetic architecture of the human cerebral cortex. / Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group.

In: Science, Vol. 367, No. 6484, aay6690, 20.03.2020.

Research output: Contribution to journalArticle

Harvard

Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group 2020, 'The genetic architecture of the human cerebral cortex', Science, vol. 367, no. 6484, aay6690. https://doi.org/10.1126/science.aay6690

APA

Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group (2020). The genetic architecture of the human cerebral cortex. Science, 367(6484), [aay6690]. https://doi.org/10.1126/science.aay6690

Vancouver

Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group. The genetic architecture of the human cerebral cortex. Science. 2020 Mar 20;367(6484). aay6690. https://doi.org/10.1126/science.aay6690

Author

Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group. / The genetic architecture of the human cerebral cortex. In: Science. 2020 ; Vol. 367, No. 6484.

Bibtex Download

@article{5a1717067c8e4596810118682ed872d9,
title = "The genetic architecture of the human cerebral cortex",
abstract = "The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.",
author = "{Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group} and Grasby, {Katrina L.} and Neda Jahanshad and Painter, {Jodie N.} and Luc{\'i}a Colodro-Conde and Janita Bralten and Hibar, {Derrek P.} and Lind, {Penelope A.} and Fabrizio Pizzagalli and Ching, {Christopher R.K.} and McMahon, {Mary Agnes B.} and Natalia Shatokhina and Zsembik, {Leo C.P.} and Thomopoulos, {Sophia I.} and Zhu, {Alyssa H.} and Strike, {Lachlan T.} and Ingrid Agartz and Saud Alhusaini and Almeida, {Marcio A.A.} and Dag Aln{\ae}s and Amlien, {Inge K.} and Micael Andersson and Tyler Ard and Armstrong, {Nicola J.} and Allison Ashley-Koch and Atkins, {Joshua R.} and Manon Bernard and Brouwer, {Rachel M.} and Buimer, {Elizabeth E.L.} and Robin B{\"u}low and Christian B{\"u}rger and Cannon, {Dara M.} and Mallar Chakravarty and Qiang Chen and Cheung, {Joshua W.} and Baptiste Couvy-Duchesne and Dale, {Anders M.} and Shareefa Dalvie and {de Araujo}, {T{\^a}nia K.} and {de Zubicaray}, {Greig I.} and {de Zwarte}, {Sonja M.C.} and {den Braber}, Anouk and Doan, {Nhat Trung} and Katharina Dohm and Tianye Jia and Tansey, {Katherine E.} and Esther Walton and Zuo Zhang and Quinlan, {Erin B.} and Sylvane Desrivi{\`e}res and Gunter Schumann",
year = "2020",
month = mar,
day = "20",
doi = "10.1126/science.aay6690",
language = "English",
volume = "367",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6484",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The genetic architecture of the human cerebral cortex

AU - Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group

AU - Grasby, Katrina L.

AU - Jahanshad, Neda

AU - Painter, Jodie N.

AU - Colodro-Conde, Lucía

AU - Bralten, Janita

AU - Hibar, Derrek P.

AU - Lind, Penelope A.

AU - Pizzagalli, Fabrizio

AU - Ching, Christopher R.K.

AU - McMahon, Mary Agnes B.

AU - Shatokhina, Natalia

AU - Zsembik, Leo C.P.

AU - Thomopoulos, Sophia I.

AU - Zhu, Alyssa H.

AU - Strike, Lachlan T.

AU - Agartz, Ingrid

AU - Alhusaini, Saud

AU - Almeida, Marcio A.A.

AU - Alnæs, Dag

AU - Amlien, Inge K.

AU - Andersson, Micael

AU - Ard, Tyler

AU - Armstrong, Nicola J.

AU - Ashley-Koch, Allison

AU - Atkins, Joshua R.

AU - Bernard, Manon

AU - Brouwer, Rachel M.

AU - Buimer, Elizabeth E.L.

AU - Bülow, Robin

AU - Bürger, Christian

AU - Cannon, Dara M.

AU - Chakravarty, Mallar

AU - Chen, Qiang

AU - Cheung, Joshua W.

AU - Couvy-Duchesne, Baptiste

AU - Dale, Anders M.

AU - Dalvie, Shareefa

AU - de Araujo, Tânia K.

AU - de Zubicaray, Greig I.

AU - de Zwarte, Sonja M.C.

AU - den Braber, Anouk

AU - Doan, Nhat Trung

AU - Dohm, Katharina

AU - Jia, Tianye

AU - Tansey, Katherine E.

AU - Walton, Esther

AU - Zhang, Zuo

AU - Quinlan, Erin B.

AU - Desrivières, Sylvane

AU - Schumann, Gunter

PY - 2020/3/20

Y1 - 2020/3/20

N2 - The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.

AB - The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.

UR - http://www.scopus.com/inward/record.url?scp=85082081461&partnerID=8YFLogxK

U2 - 10.1126/science.aay6690

DO - 10.1126/science.aay6690

M3 - Article

C2 - 32193296

AN - SCOPUS:85082081461

VL - 367

JO - Science

JF - Science

SN - 0036-8075

IS - 6484

M1 - aay6690

ER -

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454