The Genetic Links to Anxiety and Depression (GLAD) Study: Online recruitment into the largest recontactable study of depression and anxiety

Molly R Davies; Gursharan Kalsi; Cherie Armour; Ian Jones; Andrew McIntosh; Daniel J Smith; James T.R. Walters; John R. Bradley; Nathalie Kingston; Sofie Ashford; Ioana Beange; Anamaria Brailean; Anthony James Cleare; Jonathan Richard Iain Coleman; Charles John Curtis; Susannah Chloe Bailey Curzons; Katrina Alice Southworth Davis; LeRoy Downey; Victor Gault; Kimberley Ann Goldsmith; Megan Hammond Bennett; Yoriko Hirose; Matthew Hugo Hotopf; Christopher Huebel; Jennifer Leng; Bethany D Mason; Monika McAtarsney-Kovacs; Dina Monssen; Elisavet Palaiologou; Carmine Maria Pariante; Shivani Parikh; Alicia Peel; Ruth Price; Katharine Amber Rimes; Henry Charles Rogers; Megan Skelton; Anna Spaul; Eddy Leandro Almira Suarez; Bronte L Sykes; Keith Thomas; Allan Young; Evangelos Vassos; David Veale; Katie May White; Janet Wingrove; Thalia Catherine Eley; Gerome Daniel Breen

doi:10.1016/j.brat.2019.103503

The Genetic Links to Anxiety and Depression (GLAD) Study: Online recruitment into the largest recontactable study of depression and anxiety

Molly R Davies, Gursharan Kalsi, Cherie Armour, Ian Jones, Andrew McIntosh, Daniel J Smith, James T.R. Walters, John R. Bradley, Nathalie Kingston, Sofie Ashford, Ioana Beange, Anamaria Brailean, Anthony James Cleare, Jonathan Richard Iain Coleman, Charles John Curtis, Susannah Chloe Bailey Curzons, Katrina Alice Southworth Davis, LeRoy Downey, Victor Gault, Kimberley Ann GoldsmithMegan Hammond Bennett, Yoriko Hirose, Matthew Hugo Hotopf, Christopher Huebel, Jennifer Leng, Bethany D Mason, Monika McAtarsney-Kovacs, Dina Monssen, Elisavet Palaiologou, Carmine Maria Pariante, Shivani Parikh, Alicia Peel, Ruth Price, Katharine Amber Rimes, Henry Charles Rogers, Megan Skelton, Anna Spaul, Eddy Leandro Almira Suarez, Bronte L Sykes, Keith Thomas, Allan Young, Evangelos Vassos, David Veale, Katie May White, Janet Wingrove, Thalia Catherine Eley, Gerome Daniel Breen

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Abstract

Background: Anxiety and depression are common, debilitating and costly. These disorders are influenced by multiple risk factors, from genes to psychological vulnerabilities and environmental stressors, but research is hampered by a lack of sufficiently large comprehensive studies. We are recruiting 40,000 individuals with lifetime depression or anxiety and broad assessment of risks to facilitate future research. Methods: The Genetic Links to Anxiety and Depression (GLAD) Study (www.gladstudy.org.uk) recruits individuals with depression or anxiety into the NIHR Mental Health BioResource. Participants invited to join the study (via media campaigns) provide demographic, environmental and genetic data, and consent for medical record linkage and recontact. Results: Online recruitment was effective; 42,531 participants consented and 27,776 completed the questionnaire by end of July 2019. Participants’ questionnaire data identified very high rates of recurrent depression, severe anxiety, and comorbidity. Participants reported high rates of treatment receipt. The age profile of the sample is biased toward young adults, with higher recruitment of females and the more educated, especially at younger ages. Discussion: This paper describes the study methodology and descriptive data for GLAD, which represents a large, recontactable resource that will enable future research into risks, outcomes, and treatment for anxiety and depression.

Original language	English
Article number	103503
Journal	Behaviour Research and Therapy
Volume	123
Early online date	24 Oct 2019
DOIs	https://doi.org/10.1016/j.brat.2019.103503
Publication status	Published - 1 Dec 2019

Keywords

Anxiety
Behavior genetics
Data sharing
Depression
Life events
Psychiatric genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Davies, M. R., Kalsi, G., Armour, C., Jones, I., McIntosh, A., Smith, D. J., Walters, J. T. R., Bradley, J. R., Kingston, N., Ashford, S., Beange, I., Brailean, A., Cleare, A. J., Coleman, J. R. I., Curtis, C. J., Curzons, S. C. B., Davis, K. A. S., Downey, L., Gault, V., ... Breen, G. D. (2019). The Genetic Links to Anxiety and Depression (GLAD) Study: Online recruitment into the largest recontactable study of depression and anxiety. Behaviour Research and Therapy, 123, Article 103503. https://doi.org/10.1016/j.brat.2019.103503

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title = "The Genetic Links to Anxiety and Depression (GLAD) Study: Online recruitment into the largest recontactable study of depression and anxiety",

abstract = "Background: Anxiety and depression are common, debilitating and costly. These disorders are influenced by multiple risk factors, from genes to psychological vulnerabilities and environmental stressors, but research is hampered by a lack of sufficiently large comprehensive studies. We are recruiting 40,000 individuals with lifetime depression or anxiety and broad assessment of risks to facilitate future research. Methods: The Genetic Links to Anxiety and Depression (GLAD) Study (www.gladstudy.org.uk) recruits individuals with depression or anxiety into the NIHR Mental Health BioResource. Participants invited to join the study (via media campaigns) provide demographic, environmental and genetic data, and consent for medical record linkage and recontact. Results: Online recruitment was effective; 42,531 participants consented and 27,776 completed the questionnaire by end of July 2019. Participants{\textquoteright} questionnaire data identified very high rates of recurrent depression, severe anxiety, and comorbidity. Participants reported high rates of treatment receipt. The age profile of the sample is biased toward young adults, with higher recruitment of females and the more educated, especially at younger ages. Discussion: This paper describes the study methodology and descriptive data for GLAD, which represents a large, recontactable resource that will enable future research into risks, outcomes, and treatment for anxiety and depression.",

keywords = "Anxiety, Behavior genetics, Data sharing, Depression, Life events, Psychiatric genetics",

author = "Davies, {Molly R} and Gursharan Kalsi and Cherie Armour and Ian Jones and Andrew McIntosh and Smith, {Daniel J} and Walters, {James T.R.} and Bradley, {John R.} and Nathalie Kingston and Sofie Ashford and Ioana Beange and Anamaria Brailean and Cleare, {Anthony James} and Coleman, {Jonathan Richard Iain} and Curtis, {Charles John} and Curzons, {Susannah Chloe Bailey} and Davis, {Katrina Alice Southworth} and LeRoy Downey and Victor Gault and Goldsmith, {Kimberley Ann} and {Hammond Bennett}, Megan and Yoriko Hirose and Hotopf, {Matthew Hugo} and Christopher Huebel and Jennifer Leng and Mason, {Bethany D} and Monika McAtarsney-Kovacs and Dina Monssen and Elisavet Palaiologou and Pariante, {Carmine Maria} and Shivani Parikh and Alicia Peel and Ruth Price and Rimes, {Katharine Amber} and Rogers, {Henry Charles} and Megan Skelton and Anna Spaul and {Almira Suarez}, {Eddy Leandro} and Sykes, {Bronte L} and Keith Thomas and Allan Young and Evangelos Vassos and David Veale and White, {Katie May} and Janet Wingrove and Eley, {Thalia Catherine} and Breen, {Gerome Daniel}",

year = "2019",

month = dec,

day = "1",

doi = "10.1016/j.brat.2019.103503",

language = "English",

volume = "123",

journal = "Behaviour Research and Therapy",

issn = "0005-7967",

publisher = "Elsevier Limited",

}

Davies, MR , Kalsi, G, Armour, C, Jones, I, McIntosh, A, Smith, DJ, Walters, JTR, Bradley, JR, Kingston, N, Ashford, S, Beange, I, Brailean, A , Cleare, AJ , Coleman, JRI , Curtis, CJ , Curzons, SCB , Davis, KAS, Downey, L, Gault, V, Goldsmith, KA, Hammond Bennett, M, Hirose, Y, Hotopf, MH , Huebel, C, Leng, J, Mason, BD, McAtarsney-Kovacs, M , Monssen, D, Palaiologou, E, Pariante, CM, Parikh, S, Peel, A, Price, R, Rimes, KA , Rogers, HC , Skelton, M, Spaul, A, Almira Suarez, EL, Sykes, BL, Thomas, K, Young, A , Vassos, E , Veale, D , White, KM, Wingrove, J, Eley, TC & Breen, GD 2019, 'The Genetic Links to Anxiety and Depression (GLAD) Study: Online recruitment into the largest recontactable study of depression and anxiety', Behaviour Research and Therapy, vol. 123, 103503. https://doi.org/10.1016/j.brat.2019.103503

TY - JOUR

T1 - The Genetic Links to Anxiety and Depression (GLAD) Study

T2 - Online recruitment into the largest recontactable study of depression and anxiety

AU - Davies, Molly R

AU - Kalsi, Gursharan

AU - Armour, Cherie

AU - Jones, Ian

AU - McIntosh, Andrew

AU - Smith, Daniel J

AU - Walters, James T.R.

AU - Bradley, John R.

AU - Kingston, Nathalie

AU - Ashford, Sofie

AU - Beange, Ioana

AU - Brailean, Anamaria

AU - Cleare, Anthony James

AU - Coleman, Jonathan Richard Iain

AU - Curtis, Charles John

AU - Curzons, Susannah Chloe Bailey

AU - Davis, Katrina Alice Southworth

AU - Downey, LeRoy

AU - Gault, Victor

AU - Goldsmith, Kimberley Ann

AU - Hammond Bennett, Megan

AU - Hirose, Yoriko

AU - Hotopf, Matthew Hugo

AU - Huebel, Christopher

AU - Leng, Jennifer

AU - Mason, Bethany D

AU - McAtarsney-Kovacs, Monika

AU - Monssen, Dina

AU - Palaiologou, Elisavet

AU - Pariante, Carmine Maria

AU - Parikh, Shivani

AU - Peel, Alicia

AU - Price, Ruth

AU - Rimes, Katharine Amber

AU - Rogers, Henry Charles

AU - Skelton, Megan

AU - Spaul, Anna

AU - Almira Suarez, Eddy Leandro

AU - Sykes, Bronte L

AU - Thomas, Keith

AU - Young, Allan

AU - Vassos, Evangelos

AU - Veale, David

AU - White, Katie May

AU - Wingrove, Janet

AU - Eley, Thalia Catherine

AU - Breen, Gerome Daniel

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Background: Anxiety and depression are common, debilitating and costly. These disorders are influenced by multiple risk factors, from genes to psychological vulnerabilities and environmental stressors, but research is hampered by a lack of sufficiently large comprehensive studies. We are recruiting 40,000 individuals with lifetime depression or anxiety and broad assessment of risks to facilitate future research. Methods: The Genetic Links to Anxiety and Depression (GLAD) Study (www.gladstudy.org.uk) recruits individuals with depression or anxiety into the NIHR Mental Health BioResource. Participants invited to join the study (via media campaigns) provide demographic, environmental and genetic data, and consent for medical record linkage and recontact. Results: Online recruitment was effective; 42,531 participants consented and 27,776 completed the questionnaire by end of July 2019. Participants’ questionnaire data identified very high rates of recurrent depression, severe anxiety, and comorbidity. Participants reported high rates of treatment receipt. The age profile of the sample is biased toward young adults, with higher recruitment of females and the more educated, especially at younger ages. Discussion: This paper describes the study methodology and descriptive data for GLAD, which represents a large, recontactable resource that will enable future research into risks, outcomes, and treatment for anxiety and depression.

AB - Background: Anxiety and depression are common, debilitating and costly. These disorders are influenced by multiple risk factors, from genes to psychological vulnerabilities and environmental stressors, but research is hampered by a lack of sufficiently large comprehensive studies. We are recruiting 40,000 individuals with lifetime depression or anxiety and broad assessment of risks to facilitate future research. Methods: The Genetic Links to Anxiety and Depression (GLAD) Study (www.gladstudy.org.uk) recruits individuals with depression or anxiety into the NIHR Mental Health BioResource. Participants invited to join the study (via media campaigns) provide demographic, environmental and genetic data, and consent for medical record linkage and recontact. Results: Online recruitment was effective; 42,531 participants consented and 27,776 completed the questionnaire by end of July 2019. Participants’ questionnaire data identified very high rates of recurrent depression, severe anxiety, and comorbidity. Participants reported high rates of treatment receipt. The age profile of the sample is biased toward young adults, with higher recruitment of females and the more educated, especially at younger ages. Discussion: This paper describes the study methodology and descriptive data for GLAD, which represents a large, recontactable resource that will enable future research into risks, outcomes, and treatment for anxiety and depression.

KW - Anxiety

KW - Behavior genetics

KW - Data sharing

KW - Depression

KW - Life events

KW - Psychiatric genetics

UR - http://www.scopus.com/inward/record.url?scp=85074616138&partnerID=8YFLogxK

U2 - 10.1016/j.brat.2019.103503

DO - 10.1016/j.brat.2019.103503

M3 - Article

SN - 0005-7967

VL - 123

JO - Behaviour Research and Therapy

JF - Behaviour Research and Therapy

M1 - 103503

ER -

The Genetic Links to Anxiety and Depression (GLAD) Study: Online recruitment into the largest recontactable study of depression and anxiety

Abstract

Keywords

UN SDGs

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