The genetics of affective disorder and suicide

P. McGuffin; N. Perroud; R. Uher; A. Butler; K. J. Aitchison; I. Craig; C. Lewis; A. Farmer

doi:10.1016/j.eurpsy.2009.12.012

The genetics of affective disorder and suicide

P. McGuffin, N. Perroud, R. Uher, A. Butler, K. J. Aitchison, I. Craig, C. Lewis, A. Farmer

Kings Coll London, Inst Psychiat

Research output: Contribution to journal › Conference paper

60 Citations (Scopus)

Abstract

Suicidal behaviour shows evidence of familial clustering and the twin data on completed suicide suggest moderate heritability. The extent to which the genetics of suicidal behaviour overlaps with the genetics of affective disorders is unclear but there is overwhelming evidence that both bipolar and unipolar disorder are substantially influenced by genes. So far, candidate gene studies of suicidality have provoked much interest, but recently, attention has also turned to candidate gene approaches to suicidal ideation emerging during antidepressant treatment. The advent of genome-wide association studies (GWAS) has had a major impact on studies of affective disorder with some provocative new findings. The GWAS approach is also beginning to be applied in the search for genes that underlie suicidal ideation and behaviour. (C) 2010 Published by Elsevier Masson SAS.

Original language	English
Pages (from-to)	275 - 277
Number of pages	3
Journal	European Psychiatry
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.eurpsy.2009.12.012
Publication status	Published - Jun 2010
Event	Nobel Conference on the Role of Genetics in Promoting Suicide Prevention and the Mental Health of the Population - Stockholm, Sweden Duration: 8 Jun 2009 → 10 Jun 2009

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abstract = "Suicidal behaviour shows evidence of familial clustering and the twin data on completed suicide suggest moderate heritability. The extent to which the genetics of suicidal behaviour overlaps with the genetics of affective disorders is unclear but there is overwhelming evidence that both bipolar and unipolar disorder are substantially influenced by genes. So far, candidate gene studies of suicidality have provoked much interest, but recently, attention has also turned to candidate gene approaches to suicidal ideation emerging during antidepressant treatment. The advent of genome-wide association studies (GWAS) has had a major impact on studies of affective disorder with some provocative new findings. The GWAS approach is also beginning to be applied in the search for genes that underlie suicidal ideation and behaviour. (C) 2010 Published by Elsevier Masson SAS.",

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AU - McGuffin, P.

AU - Perroud, N.

AU - Uher, R.

AU - Butler, A.

AU - Aitchison, K. J.

AU - Craig, I.

AU - Lewis, C.

AU - Farmer, A.

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AB - Suicidal behaviour shows evidence of familial clustering and the twin data on completed suicide suggest moderate heritability. The extent to which the genetics of suicidal behaviour overlaps with the genetics of affective disorders is unclear but there is overwhelming evidence that both bipolar and unipolar disorder are substantially influenced by genes. So far, candidate gene studies of suicidality have provoked much interest, but recently, attention has also turned to candidate gene approaches to suicidal ideation emerging during antidepressant treatment. The advent of genome-wide association studies (GWAS) has had a major impact on studies of affective disorder with some provocative new findings. The GWAS approach is also beginning to be applied in the search for genes that underlie suicidal ideation and behaviour. (C) 2010 Published by Elsevier Masson SAS.

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DO - 10.1016/j.eurpsy.2009.12.012

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SN - 1778-3585

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Y2 - 8 June 2009 through 10 June 2009

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The genetics of affective disorder and suicide

Abstract

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