Research output: Contribution to journal › Article › peer-review
Moritz Herle, Mohamed Abdulkadir, Christopher Hubel, Diana Santos Ferreira, Rachel Bryant-Waugh, Ruth Loos, Cynthia M. Bulik, Bianca De Stavola, Nadia Micali
Original language | English |
---|---|
Pages (from-to) | 625-630 |
Number of pages | 6 |
Journal | Nature Human Behaviour |
Volume | 5 |
Issue number | 5 |
Early online date | 11 Jan 2021 |
DOIs | |
E-pub ahead of print | 11 Jan 2021 |
Published | May 2021 |
Additional links |
Eating behaviours may be expressions of genetic risk for obesity and are potential antecedents of later eating disorders. However, childhood eating behaviours are heterogeneous and transient. Here we show associations between polygenic scores for body mass index (BMI-PGS) and anorexia nervosa (AN-PGS) with eating behaviour trajectories during the first 10 years of life using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), n = 7,825. Results indicated that 1 s.d. increase in the BMI-PGS was associated with a 30-37% increased risk for early- and mid-childhood overeating. In contrast, 1 s.d. increase in BMI-PGS was associated with a 20% decrease in risk of persistent high levels of undereating and a 15% decrease in risk of persistent fussy eating. There was no evidence for a significant association between AN-PGS and eating behaviour trajectories. Our results support the notion that child eating behaviours share common genetic variants associated with BMI.
King's College London - Homepage
© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454