The HBS1L - MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.

Stephan Menzel; J Jiang; N Silver; J Gallagher; J Cunningham; G Surdulescu; M Lathrop; M Farrall; TD Spector; SL Thein

doi:10.1182/blood-2007-05-093419

The HBS1L - MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.

Stephan Menzel, J Jiang, N Silver, J Gallagher, J Cunningham, G Surdulescu, M Lathrop, M Farrall, TD Spector, SL Thein

Medical & Molecular Genetics

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematological parameters. Here we show a significant impact of HMIP variability on several types of peripheral blood cells: erythrocyte, platelet and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans.

Original language	English
Pages (from-to)	3624 - 3626
Number of pages	3
Journal	Blood
Volume	110
Issue number	10
DOIs	https://doi.org/10.1182/blood-2007-05-093419
Publication status	Published - 15 Nov 2007

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title = "The HBS1L - MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.",

abstract = "Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematological parameters. Here we show a significant impact of HMIP variability on several types of peripheral blood cells: erythrocyte, platelet and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans. ",

author = "Stephan Menzel and J Jiang and N Silver and J Gallagher and J Cunningham and G Surdulescu and M Lathrop and M Farrall and TD Spector and SL Thein",

year = "2007",

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doi = "10.1182/blood-2007-05-093419",

language = "English",

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T1 - The HBS1L - MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.

AU - Menzel, Stephan

AU - Jiang, J

AU - Silver, N

AU - Gallagher, J

AU - Cunningham, J

AU - Surdulescu, G

AU - Lathrop, M

AU - Farrall, M

AU - Spector, TD

AU - Thein, SL

PY - 2007/11/15

Y1 - 2007/11/15

N2 - Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematological parameters. Here we show a significant impact of HMIP variability on several types of peripheral blood cells: erythrocyte, platelet and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans.

AB - Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematological parameters. Here we show a significant impact of HMIP variability on several types of peripheral blood cells: erythrocyte, platelet and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans.

U2 - 10.1182/blood-2007-05-093419

DO - 10.1182/blood-2007-05-093419

M3 - Article

SN - 1528-0020

VL - 110

SP - 3624

EP - 3626

JO - Blood

JF - Blood

IS - 10

ER -

The HBS1L - MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.

Abstract

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