The hematologic manifestations of the antiphospholipid syndrome

TY - JOUR

T1 - The hematologic manifestations of the antiphospholipid syndrome

AU - Uthman, I

AU - Godeau, B

AU - Taher, A

AU - Khamashta, M

PY - 2008/7

Y1 - 2008/7

N2 - Various hematological pathologies have been described in association with antiphospholipid syndrome (APS). Thrombocytopenia is frequently found in APS patients, its incidence has ranged from 22-42% in different series, it is usually moderate (>50 x 10(9)/L) without clinical manifestation and requires no intervention. A high percentage of patients with isolated idiopathic thrombocytopenic purpura have anti phospholipid antibodies, however the pathogenetic role and the clinical importance of these antibodies in this condition is still not clear. Other hematological manifestations reported in association with APS include: bone marrow necrosis, and various thrombotic microangiopathic syndromes Such as: thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome, HELLP (hemolysis, elevated liver enzymes, low platelet) syndrome, and catastrophic APS. A high index of suspicion is needed for the early recognition and treatment of these conditions. (C) 2008 Elsevier Ltd. All rights reserved

AB - Various hematological pathologies have been described in association with antiphospholipid syndrome (APS). Thrombocytopenia is frequently found in APS patients, its incidence has ranged from 22-42% in different series, it is usually moderate (>50 x 10(9)/L) without clinical manifestation and requires no intervention. A high percentage of patients with isolated idiopathic thrombocytopenic purpura have anti phospholipid antibodies, however the pathogenetic role and the clinical importance of these antibodies in this condition is still not clear. Other hematological manifestations reported in association with APS include: bone marrow necrosis, and various thrombotic microangiopathic syndromes Such as: thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome, HELLP (hemolysis, elevated liver enzymes, low platelet) syndrome, and catastrophic APS. A high index of suspicion is needed for the early recognition and treatment of these conditions. (C) 2008 Elsevier Ltd. All rights reserved

U2 - 10.1016/j.blre.2008.03.005

DO - 10.1016/j.blre.2008.03.005

M3 - Literature review

VL - 22

SP - 187

EP - 194

JO - Blood Reviews

JF - Blood Reviews

IS - 4

ER -