The hippocampus and panic disorder: Evidence from animal and human studies

TY - CHAP

T1 - The hippocampus and panic disorder

T2 - Evidence from animal and human studies

AU - Dias, Gisele Pereira

AU - Thuret, Sandrine

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Panic disorder (PD) is a highly incapacitating psychiatric disorder. Its wide range of somatic and psychological symptoms makes it plausible that a number of different brain structures and circuits are likely to mediate this condition. In this chapter we highlight the possible contributions of the hippocampus, a key brain region involved in the regulation of cognition (learning/memory), mood and defensive responses (fear/anxiety), for the pathophysiology of PD. This chapter will present the anatomy of the hippocampus and highlight its role in emotional regulation, so that an understanding of the involvement of the hippocampus in PD can be drawn. Evidence from both animal and human findings on this topic will be approached. Particularly, the capacity of the hippocampus to continually generate newly functional neurons throughout life, a phenomenon called adult hippocampal neurogenesis, will be pointed as part of the key future directions for the study of the neurobiological basis of PD.

AB - Panic disorder (PD) is a highly incapacitating psychiatric disorder. Its wide range of somatic and psychological symptoms makes it plausible that a number of different brain structures and circuits are likely to mediate this condition. In this chapter we highlight the possible contributions of the hippocampus, a key brain region involved in the regulation of cognition (learning/memory), mood and defensive responses (fear/anxiety), for the pathophysiology of PD. This chapter will present the anatomy of the hippocampus and highlight its role in emotional regulation, so that an understanding of the involvement of the hippocampus in PD can be drawn. Evidence from both animal and human findings on this topic will be approached. Particularly, the capacity of the hippocampus to continually generate newly functional neurons throughout life, a phenomenon called adult hippocampal neurogenesis, will be pointed as part of the key future directions for the study of the neurobiological basis of PD.

KW - Animal models

KW - Anxiety

KW - Fear circuitry

KW - Hippocampus

KW - Panic disorder

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=85012202210&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-12538-1_3

DO - 10.1007/978-3-319-12538-1_3

M3 - Chapter

AN - SCOPUS:85012202210

SN - 9783319125381

SN - 9783319125374

SP - 79

EP - 91

BT - Panic Disorder: Neurobiological and Treatment Aspects

PB - Springer International Publishing Switzerland

ER -