The HPA axis in major depression: classical theories and new developments

Carmine M. Pariante, Stafford L. Lightman

Research output: Contribution to journalLiterature reviewpeer-review

1449 Citations (Scopus)

Abstract

Studies over the last 40 years have demonstrated that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.
Original languageEnglish
Pages (from-to)464 - 468
Number of pages5
JournalTrends in Neurosciences
Volume31
Issue number9
DOIs
Publication statusPublished - Sept 2008

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