The HPA axis in major depression: classical theories and new developments

Carmine M. Pariante; Stafford L. Lightman

doi:10.1016/j.tins.2008.06.006

The HPA axis in major depression: classical theories and new developments

Carmine M. Pariante, Stafford L. Lightman

Research output: Contribution to journal › Literature review › peer-review

1562 Citations (Scopus)

Abstract

Studies over the last 40 years have demonstrated that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.

Original language	English
Pages (from-to)	464 - 468
Number of pages	5
Journal	Trends in Neurosciences
Volume	31
Issue number	9
DOIs	https://doi.org/10.1016/j.tins.2008.06.006
Publication status	Published - Sept 2008

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title = "The HPA axis in major depression: classical theories and new developments",

abstract = "Studies over the last 40 years have demonstrated that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.",

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AU - Lightman, Stafford L.

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AB - Studies over the last 40 years have demonstrated that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.

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DO - 10.1016/j.tins.2008.06.006

M3 - Literature review

VL - 31

SP - 464

EP - 468

JO - Trends in Neurosciences

JF - Trends in Neurosciences

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ER -

The HPA axis in major depression: classical theories and new developments

Abstract

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