The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus

Anna Hellquist; Marco Zucchelli; Katja Kivinen; Ulpu Saarialho-Kere; Sari Koskenmies; Elisabeth Widen; Heikki Julkunen; Andrew Wong; Marja-Liisa Karjalainen-Lindsberg; Tiina Skoog; Johanna Vendelin; Deborah S Cunninghame-Graham; Timothy J Vyse; Juha Kere; Cecilia M Lindgren; Deborah Cunninghame Graham

doi:10.1136/jmg.2006.046185

The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus

Anna Hellquist, Marco Zucchelli, Katja Kivinen, Ulpu Saarialho-Kere, Sari Koskenmies, Elisabeth Widen, Heikki Julkunen, Andrew Wong, Marja-Liisa Karjalainen-Lindsberg, Tiina Skoog, Johanna Vendelin, Deborah S Cunninghame-Graham, Timothy J Vyse, Juha Kere, Cecilia M Lindgren, Deborah Cunninghame Graham

Medical & Molecular Genetics

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

Several members of the GIMAP gene family have been suggested as being involved in different aspects of the immune system in different species. Recently, a mutation in the GIMAP5 gene was shown to cause lymphopenia in a rat model of autoimmune insulin-dependent diabetes. Thus it was hypothesised that genetic variation in GIMAP5 may be involved in susceptibility to other autoimmune disorders where lymphopenia is a key feature, such as systemic lupus erythematosus (SLE). Material and

Original language	English
Pages (from-to)	314-321
Number of pages	8
Journal	Journal of Medical Genetics
Volume	44
Issue number	5
Early online date	12 Jan 2007
DOIs	https://doi.org/10.1136/jmg.2006.046185
Publication status	Published - May 2007

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10.1136/jmg.2006.046185

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Hellquist, A., Zucchelli, M., Kivinen, K., Saarialho-Kere, U., Koskenmies, S., Widen, E., Julkunen, H., Wong, A., Karjalainen-Lindsberg, M.-L., Skoog, T., Vendelin, J., Cunninghame-Graham, D. S., Vyse, T. J., Kere, J., Lindgren, C. M., & Cunninghame Graham, D. (2007). The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus. Journal of Medical Genetics, 44(5), 314-321. https://doi.org/10.1136/jmg.2006.046185

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title = "The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus",

abstract = "Several members of the GIMAP gene family have been suggested as being involved in different aspects of the immune system in different species. Recently, a mutation in the GIMAP5 gene was shown to cause lymphopenia in a rat model of autoimmune insulin-dependent diabetes. Thus it was hypothesised that genetic variation in GIMAP5 may be involved in susceptibility to other autoimmune disorders where lymphopenia is a key feature, such as systemic lupus erythematosus (SLE). Material and",

author = "Anna Hellquist and Marco Zucchelli and Katja Kivinen and Ulpu Saarialho-Kere and Sari Koskenmies and Elisabeth Widen and Heikki Julkunen and Andrew Wong and Marja-Liisa Karjalainen-Lindsberg and Tiina Skoog and Johanna Vendelin and Cunninghame-Graham, {Deborah S} and Vyse, {Timothy J} and Juha Kere and Lindgren, {Cecilia M} and {Cunninghame Graham}, Deborah",

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Hellquist, A, Zucchelli, M, Kivinen, K, Saarialho-Kere, U, Koskenmies, S, Widen, E, Julkunen, H, Wong, A, Karjalainen-Lindsberg, M-L, Skoog, T, Vendelin, J, Cunninghame-Graham, DS, Vyse, TJ, Kere, J, Lindgren, CM & Cunninghame Graham, D 2007, 'The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus', Journal of Medical Genetics, vol. 44, no. 5, pp. 314-321. https://doi.org/10.1136/jmg.2006.046185

TY - JOUR

T1 - The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus

AU - Hellquist, Anna

AU - Zucchelli, Marco

AU - Kivinen, Katja

AU - Saarialho-Kere, Ulpu

AU - Koskenmies, Sari

AU - Widen, Elisabeth

AU - Julkunen, Heikki

AU - Wong, Andrew

AU - Karjalainen-Lindsberg, Marja-Liisa

AU - Skoog, Tiina

AU - Vendelin, Johanna

AU - Cunninghame-Graham, Deborah S

AU - Vyse, Timothy J

AU - Kere, Juha

AU - Lindgren, Cecilia M

AU - Cunninghame Graham, Deborah

PY - 2007/5

Y1 - 2007/5

N2 - Several members of the GIMAP gene family have been suggested as being involved in different aspects of the immune system in different species. Recently, a mutation in the GIMAP5 gene was shown to cause lymphopenia in a rat model of autoimmune insulin-dependent diabetes. Thus it was hypothesised that genetic variation in GIMAP5 may be involved in susceptibility to other autoimmune disorders where lymphopenia is a key feature, such as systemic lupus erythematosus (SLE). Material and

AB - Several members of the GIMAP gene family have been suggested as being involved in different aspects of the immune system in different species. Recently, a mutation in the GIMAP5 gene was shown to cause lymphopenia in a rat model of autoimmune insulin-dependent diabetes. Thus it was hypothesised that genetic variation in GIMAP5 may be involved in susceptibility to other autoimmune disorders where lymphopenia is a key feature, such as systemic lupus erythematosus (SLE). Material and

U2 - 10.1136/jmg.2006.046185

DO - 10.1136/jmg.2006.046185

M3 - Article

C2 - 17220214

SN - 1468-6244

VL - 44

SP - 314

EP - 321

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

IS - 5

ER -

The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus

Abstract

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