The impact of auditory hallucinations on “living well” with dementia: Findings from the IDEAL programme

IDEAL Programme Team

doi:10.1002/gps.5533

The impact of auditory hallucinations on “living well” with dementia: Findings from the IDEAL programme

IDEAL Programme Team

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Objective: To determine whether auditory hallucinations in community-dwelling people with dementia (PwD) living in the community impacted on quality of life (QoL), subjective wellbeing and life satisfaction. Design: Cross-sectional cohort study. Settings and participants: 1251 community-dwelling PwD and caregivers were included in this study. Measures: Neuropsychiatric Inventory Questionnaire completed by caregiver interview. Mean differences between the absence and presence of auditory hallucinations were compared to scores on three validated measures of living well: QoL in Alzheimer's disease scale (QoL-AD), World Health Organization-Five Well-being Index and Satisfaction with Life Scale. Analysis of covariance determined the confounding contributions of cognition via Mini-Mental State Examination, depression via Geriatric Depression Scale-10, caregiver stress via Relative Stress Scale and whether antipsychotic drugs were prescribed. Results: Auditory hallucinations were associated with lower scores for QoL (p < 0.001, η² = 0.01), wellbeing (p < 0.001, η² = 0.02) and life satisfaction (p < 0.001, η² = 0.01). After controlling for background measures, which were potential confounds, the relationship between auditory hallucinations and QoL (p = 0.04, pη² = 0.01) and wellbeing (p < 0.000, pη² = 0.02) remained significant but there was no significant association with life satisfaction. Conclusion: Auditory hallucinations are associated with lower QoL and wellbeing in PwD living in the community. This has implications for targeted therapies in PwD with psychotic symptoms.

Original language	English
Pages (from-to)	1370-1377
Number of pages	8
Journal	International Journal of Geriatric Psychiatry
Volume	36
Issue number	9
DOIs	https://doi.org/10.1002/gps.5533
Publication status	Published - Sept 2021

Keywords

psychosis
quality of life
satisfaction with life
wellbeing

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10.1002/gps.5533

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@article{5cc1992d34394f1ab18ce679f6815015,

title = "The impact of auditory hallucinations on “living well” with dementia: Findings from the IDEAL programme",

abstract = "Objective: To determine whether auditory hallucinations in community-dwelling people with dementia (PwD) living in the community impacted on quality of life (QoL), subjective wellbeing and life satisfaction. Design: Cross-sectional cohort study. Settings and participants: 1251 community-dwelling PwD and caregivers were included in this study. Measures: Neuropsychiatric Inventory Questionnaire completed by caregiver interview. Mean differences between the absence and presence of auditory hallucinations were compared to scores on three validated measures of living well: QoL in Alzheimer's disease scale (QoL-AD), World Health Organization-Five Well-being Index and Satisfaction with Life Scale. Analysis of covariance determined the confounding contributions of cognition via Mini-Mental State Examination, depression via Geriatric Depression Scale-10, caregiver stress via Relative Stress Scale and whether antipsychotic drugs were prescribed. Results: Auditory hallucinations were associated with lower scores for QoL (p < 0.001, η2 = 0.01), wellbeing (p < 0.001, η2 = 0.02) and life satisfaction (p < 0.001, η2 = 0.01). After controlling for background measures, which were potential confounds, the relationship between auditory hallucinations and QoL (p = 0.04, pη2 = 0.01) and wellbeing (p < 0.000, pη2 = 0.02) remained significant but there was no significant association with life satisfaction. Conclusion: Auditory hallucinations are associated with lower QoL and wellbeing in PwD living in the community. This has implications for targeted therapies in PwD with psychotic symptoms.",

keywords = "psychosis, quality of life, satisfaction with life, wellbeing",

author = "{IDEAL Programme Team} and Aaron Choi and Clive Ballard and Anthony Martyr and Rachel Collins and Morris, {Robin G.} and Linda Clare",

note = "Funding Information: We would like to acknowledge the support of the following research networks: NIHR Dementias and Neurodegeneration Specialty (DeNDRoN) in England, the Scottish Dementia Clinical Research Network (SDCRN), and Health and Care Research Wales. We gratefully acknowledge the local principal investigators and researchers involved in participant recruitment and assessment within these networks. We thank the members of the ALWAYs group and the Project Advisory Group for their support with the study. We would also like to thank Professor Fiona Matthews and Dr Laura Gamble for statistical advice. A. Choi is funded jointly by The Bateman Family Charitable Trust & the University of Exeter Diamond Jubilee Doctoral Scholarship Match Fund scheme. L. Clare acknowledges support from the National Institute for Health Research Applied Research Collaboration South West Peninsula. “Improving the experience of Dementia and Enhancing Active Life: living well with dementia. The IDEAL study” was funded jointly by the Economic and Social Research Council (ESRC) and the National Institute for Health Research (NIHR) through grant ES/L001853/2. Investigators: L. Clare, I.R. Jones, C. Victor, J.V. Hindle, R.W. Jones, M. Knapp, M.D. Kopelman, R. Litherland, A. Martyr, F.E. Matthews, R.G. Morris, S.M. Nelis, J.A. Pickett, C. Quinn, J.M. Rusted, J.M. Thom. ESRC is part of UK Research and Innovation (UKRI). “Improving the experience of Dementia and Enhancing Active Life: a longitudinal perspective on living well with dementia. The IDEAL‐2 study” is funded by Alzheimer's Society, grant number 348, AS‐PR2‐16‐001. Investigators: L. Clare, I.R. Jones, C. Victor, C. Ballard, A. Hillman, J.V. Hindle, J. Hughes, R.W. Jones, M. Knapp, R. Litherland, A. Martyr, F.E. Matthews, R.G. Morris, S.M. Nelis, C. Quinn, J.M. Rusted. The views expressed are those of the author(s) and not necessarily those of the ESRC, UKRI, NIHR, the Department of Health and Social Care, the National Health Service, or Alzheimer's Society. The support of ESRC, NIHR and Alzheimer's Society is gratefully acknowledged. Publisher Copyright: {\textcopyright} 2021 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = sep,

doi = "10.1002/gps.5533",

language = "English",

volume = "36",

pages = "1370--1377",

journal = "International Journal of Geriatric Psychiatry",

issn = "0885-6230",

publisher = "John Wiley and sons",

number = "9",

}

TY - JOUR

T1 - The impact of auditory hallucinations on “living well” with dementia

T2 - Findings from the IDEAL programme

AU - IDEAL Programme Team

AU - Choi, Aaron

AU - Ballard, Clive

AU - Martyr, Anthony

AU - Collins, Rachel

AU - Morris, Robin G.

AU - Clare, Linda

N1 - Funding Information: We would like to acknowledge the support of the following research networks: NIHR Dementias and Neurodegeneration Specialty (DeNDRoN) in England, the Scottish Dementia Clinical Research Network (SDCRN), and Health and Care Research Wales. We gratefully acknowledge the local principal investigators and researchers involved in participant recruitment and assessment within these networks. We thank the members of the ALWAYs group and the Project Advisory Group for their support with the study. We would also like to thank Professor Fiona Matthews and Dr Laura Gamble for statistical advice. A. Choi is funded jointly by The Bateman Family Charitable Trust & the University of Exeter Diamond Jubilee Doctoral Scholarship Match Fund scheme. L. Clare acknowledges support from the National Institute for Health Research Applied Research Collaboration South West Peninsula. “Improving the experience of Dementia and Enhancing Active Life: living well with dementia. The IDEAL study” was funded jointly by the Economic and Social Research Council (ESRC) and the National Institute for Health Research (NIHR) through grant ES/L001853/2. Investigators: L. Clare, I.R. Jones, C. Victor, J.V. Hindle, R.W. Jones, M. Knapp, M.D. Kopelman, R. Litherland, A. Martyr, F.E. Matthews, R.G. Morris, S.M. Nelis, J.A. Pickett, C. Quinn, J.M. Rusted, J.M. Thom. ESRC is part of UK Research and Innovation (UKRI). “Improving the experience of Dementia and Enhancing Active Life: a longitudinal perspective on living well with dementia. The IDEAL‐2 study” is funded by Alzheimer's Society, grant number 348, AS‐PR2‐16‐001. Investigators: L. Clare, I.R. Jones, C. Victor, C. Ballard, A. Hillman, J.V. Hindle, J. Hughes, R.W. Jones, M. Knapp, R. Litherland, A. Martyr, F.E. Matthews, R.G. Morris, S.M. Nelis, C. Quinn, J.M. Rusted. The views expressed are those of the author(s) and not necessarily those of the ESRC, UKRI, NIHR, the Department of Health and Social Care, the National Health Service, or Alzheimer's Society. The support of ESRC, NIHR and Alzheimer's Society is gratefully acknowledged. Publisher Copyright: © 2021 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/9

Y1 - 2021/9

N2 - Objective: To determine whether auditory hallucinations in community-dwelling people with dementia (PwD) living in the community impacted on quality of life (QoL), subjective wellbeing and life satisfaction. Design: Cross-sectional cohort study. Settings and participants: 1251 community-dwelling PwD and caregivers were included in this study. Measures: Neuropsychiatric Inventory Questionnaire completed by caregiver interview. Mean differences between the absence and presence of auditory hallucinations were compared to scores on three validated measures of living well: QoL in Alzheimer's disease scale (QoL-AD), World Health Organization-Five Well-being Index and Satisfaction with Life Scale. Analysis of covariance determined the confounding contributions of cognition via Mini-Mental State Examination, depression via Geriatric Depression Scale-10, caregiver stress via Relative Stress Scale and whether antipsychotic drugs were prescribed. Results: Auditory hallucinations were associated with lower scores for QoL (p < 0.001, η2 = 0.01), wellbeing (p < 0.001, η2 = 0.02) and life satisfaction (p < 0.001, η2 = 0.01). After controlling for background measures, which were potential confounds, the relationship between auditory hallucinations and QoL (p = 0.04, pη2 = 0.01) and wellbeing (p < 0.000, pη2 = 0.02) remained significant but there was no significant association with life satisfaction. Conclusion: Auditory hallucinations are associated with lower QoL and wellbeing in PwD living in the community. This has implications for targeted therapies in PwD with psychotic symptoms.

AB - Objective: To determine whether auditory hallucinations in community-dwelling people with dementia (PwD) living in the community impacted on quality of life (QoL), subjective wellbeing and life satisfaction. Design: Cross-sectional cohort study. Settings and participants: 1251 community-dwelling PwD and caregivers were included in this study. Measures: Neuropsychiatric Inventory Questionnaire completed by caregiver interview. Mean differences between the absence and presence of auditory hallucinations were compared to scores on three validated measures of living well: QoL in Alzheimer's disease scale (QoL-AD), World Health Organization-Five Well-being Index and Satisfaction with Life Scale. Analysis of covariance determined the confounding contributions of cognition via Mini-Mental State Examination, depression via Geriatric Depression Scale-10, caregiver stress via Relative Stress Scale and whether antipsychotic drugs were prescribed. Results: Auditory hallucinations were associated with lower scores for QoL (p < 0.001, η2 = 0.01), wellbeing (p < 0.001, η2 = 0.02) and life satisfaction (p < 0.001, η2 = 0.01). After controlling for background measures, which were potential confounds, the relationship between auditory hallucinations and QoL (p = 0.04, pη2 = 0.01) and wellbeing (p < 0.000, pη2 = 0.02) remained significant but there was no significant association with life satisfaction. Conclusion: Auditory hallucinations are associated with lower QoL and wellbeing in PwD living in the community. This has implications for targeted therapies in PwD with psychotic symptoms.

KW - psychosis

KW - quality of life

KW - satisfaction with life

KW - wellbeing

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U2 - 10.1002/gps.5533

DO - 10.1002/gps.5533

M3 - Article

C2 - 33734483

AN - SCOPUS:85103152207

SN - 0885-6230

VL - 36

SP - 1370

EP - 1377

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

IS - 9

ER -

The impact of auditory hallucinations on “living well” with dementia: Findings from the IDEAL programme

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Keywords

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