The Impact of Fatigue on Sleep and Other Non-Motor Symptoms in Parkinson’s Disease

TY - JOUR

T1 - The Impact of Fatigue on Sleep and Other Non-Motor Symptoms in Parkinson’s Disease

AU - Diaconu, Stefania

AU - Monescu, Vlad

AU - Filip, Rafaela

AU - Marian, Laura

AU - Kakucs, Cristian

AU - Murasan, Iulia

AU - Chaudhuri, K. Ray

AU - Jianu, Dragos Catalin

AU - Falup-Pecurariu, Cristian

AU - Opritoiu, Bianca

N1 - Publisher Copyright: © 2024 by the authors.

PY - 2024/4/19

Y1 - 2024/4/19

N2 - Fatigue is a common non-motor symptom in Parkinson’s disease (PD), but even so, it may still be underdiagnosed or misdiagnosed in current practice due to its non-specific manifestations. The aims of this study were to investigate the prevalence of fatigue in PD patients compared to healthy controls and to identify the main characteristics and associations of fatigue with other non-motor symptoms and the impact of fatigue on sleep disturbances in Parkinson’s disease. Materials and methods: case–control study in which 131 PD patients and 131 age- and sex-matched controls were enrolled. Main characteristics of fatigue, sleep, and other non-motor symptoms were assessed using specific validated questionnaires. Results: According to the Chalder fatigue scale, fatigue is more prevalent in PD patients (38.16%) compared to healthy controls (26.71%). Fatigue was identified in 46.54% of the PD patients using the Parkinson’s Fatigue Scale (PFS-16). PD patients with fatigue presented a worse motor status, more sleep disturbances (insomnia, daytime sleepiness), a broader spectrum of non-motor symptoms (pain, anxiety, urinary disturbances), worse cognitive performances, a lower level of happiness, and worse quality of life compared to PD patients without fatigue. Conclusion: Fatigue is a common symptom of PD and needs to be assessed, considering its consequences on quality of life. Sleep disturbances have a great influence over fatigue in PD patients.

AB - Fatigue is a common non-motor symptom in Parkinson’s disease (PD), but even so, it may still be underdiagnosed or misdiagnosed in current practice due to its non-specific manifestations. The aims of this study were to investigate the prevalence of fatigue in PD patients compared to healthy controls and to identify the main characteristics and associations of fatigue with other non-motor symptoms and the impact of fatigue on sleep disturbances in Parkinson’s disease. Materials and methods: case–control study in which 131 PD patients and 131 age- and sex-matched controls were enrolled. Main characteristics of fatigue, sleep, and other non-motor symptoms were assessed using specific validated questionnaires. Results: According to the Chalder fatigue scale, fatigue is more prevalent in PD patients (38.16%) compared to healthy controls (26.71%). Fatigue was identified in 46.54% of the PD patients using the Parkinson’s Fatigue Scale (PFS-16). PD patients with fatigue presented a worse motor status, more sleep disturbances (insomnia, daytime sleepiness), a broader spectrum of non-motor symptoms (pain, anxiety, urinary disturbances), worse cognitive performances, a lower level of happiness, and worse quality of life compared to PD patients without fatigue. Conclusion: Fatigue is a common symptom of PD and needs to be assessed, considering its consequences on quality of life. Sleep disturbances have a great influence over fatigue in PD patients.

KW - anxiety

KW - depression

KW - fatigue

KW - Parkinson’s disease

KW - quality of life

KW - sleep disturbances

UR - https://www.scopus.com/pages/publications/85191571967

U2 - 10.3390/brainsci14040397

DO - 10.3390/brainsci14040397

M3 - Article

AN - SCOPUS:85191571967

SN - 2076-3425

VL - 14

JO - Brain Sciences

JF - Brain Sciences

IS - 4

M1 - 397

ER -