The impact of substance use at psychosis onset on First Episode Psychosis course: Results from a 1 year follow-up study in Bologna

Ilaria Tarricone*, Jane Boydell, Serena Panigada, Fabio Allegri, Thomas Marcacci, Maria Gabriella Minenna, Arnisa Kokona, Federico Triolo, Viviana Storbini, Rossella Michetti, Craig Morgan, Marta di Forti, Robin M. Murray, Domenico Berardi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Objectives: Substance abuse is a well established risk factor for First-Episode Psychosis (FEP), but its influence on FEP course is less clear. Starting from our baseline observation that substance users were younger than non-users at the psychosis onset, we hypothesized that substance use at baseline could be an independent risk factor for a worse clinical course.

Methods: An incidence cohort of patients with FEP collected in an 8 year period (2002-2009) at the Bologna West Community Mental Health Centers (CMHCs) was assessed at baseline and at 12 month follow-up. Drop-out, hospitalizations and service utilization were used as clinical outcomes.

Results: Most of the patients were still in contact with CMHC at 12 month follow up. Substance users had a significantly higher rate of hospitalizations during the follow-up after adjusting for age, gender and other potential confounders (OR 5.84, 95% CI 2.44-13.97, p <= 0.001).

Conclusions: This study adds to previous evidence showing the independent effect of substance use on FEP course. The identification of a "potentially modifiable" environmental predictor of the course of the illness such as substance use at psychosis onset allows us to envisage the possibility of ameliorating the course of the illness by managing this factor.

Original languageEnglish
Pages (from-to)60-63
Number of pages4
JournalSchizophrenia Research
Volume153
Issue number1-3
DOIs
Publication statusPublished - Mar 2014

Keywords

  • First episode psychosis
  • Substance use
  • Psychosis course
  • CANNABIS USE
  • 1ST-EPISODE PSYCHOSIS
  • SCHIZOPHRENIA
  • RISK
  • SERVICE
  • RELAPSE
  • COHORT

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