The influence of insulin on anticipation and consummatory reward to food intake: A functional imaging study on healthy normal weight and overweight subjects employing intranasal insulin delivery

TY - JOUR

T1 - The influence of insulin on anticipation and consummatory reward to food intake

T2 - A functional imaging study on healthy normal weight and overweight subjects employing intranasal insulin delivery

AU - Wingrove, Jed

AU - O'Daly, Owen

AU - De Lara Rubio, Alfonso

AU - Hill, Simon

AU - Swedroska, Magda

AU - Forbes, Ben

AU - Amiel, Stephanie

AU - Zelaya, Fernando

N1 - Funding Information: The authors declare that this study received funding from Unilever UK. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication. Funding Information: The authors would like to thank all the radiographers and participants for allowing this project to be undertaken. The authors would also like to thank Louise Brown who was previously employed at Unilever UK for gaining the funds to conduct the fMRI taste aspect of this work. Funding Information: EPSRC CASE EP/L015226/1 provided funding for the project and Jed Wingrove; financial support for the project was also provided by Unilever UK. Publisher Copyright: © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.

PY - 2022/12/15

Y1 - 2022/12/15

N2 - Aberrant responses within homeostatic, hedonic and cognitive systems contribute to poor appetite control in those with an overweight phenotype. The hedonic system incorporates limbic and meso-limbic regions involved in learning and reward processing, as well as cortical regions involved in motivation, decision making and gustatory processing. Equally important within this complex, multifaceted framework are the cognitive systems involved in inhibitory control and valuation of food choices. Regions within these systems display insulin receptors and pharmacologically increasing central insulin concentrations using intranasal administration (IN-INS) has been shown to significantly reduce appealing food cue responsiveness and also food intake. In this work we describe a placebo-controlled crossover pharmacological functional magnetic resonance imaging (fMRI) study that looks at how IN-INS (160 IU) affects anticipatory and consummatory responses to sweet stimuli and importantly how these responses differ between healthy normal weight and overweight male individuals. This work shows that age matched normal weight and overweight (not obese) individuals respond similarly to both the anticipation and receipt of sweet stimuli under placebo conditions. However, increased central insulin concentrations produce marked differences between groups when anticipating sweet stimuli within the prefrontal cortex and midbrain as well as observed differences in the amygdala during consummatory responses.

AB - Aberrant responses within homeostatic, hedonic and cognitive systems contribute to poor appetite control in those with an overweight phenotype. The hedonic system incorporates limbic and meso-limbic regions involved in learning and reward processing, as well as cortical regions involved in motivation, decision making and gustatory processing. Equally important within this complex, multifaceted framework are the cognitive systems involved in inhibitory control and valuation of food choices. Regions within these systems display insulin receptors and pharmacologically increasing central insulin concentrations using intranasal administration (IN-INS) has been shown to significantly reduce appealing food cue responsiveness and also food intake. In this work we describe a placebo-controlled crossover pharmacological functional magnetic resonance imaging (fMRI) study that looks at how IN-INS (160 IU) affects anticipatory and consummatory responses to sweet stimuli and importantly how these responses differ between healthy normal weight and overweight male individuals. This work shows that age matched normal weight and overweight (not obese) individuals respond similarly to both the anticipation and receipt of sweet stimuli under placebo conditions. However, increased central insulin concentrations produce marked differences between groups when anticipating sweet stimuli within the prefrontal cortex and midbrain as well as observed differences in the amygdala during consummatory responses.

KW - anticipation

KW - consummatory

KW - functional imaging

KW - intranasal insulin

KW - overweight

UR - http://www.scopus.com/inward/record.url?scp=85134370482&partnerID=8YFLogxK

U2 - 10.1002/hbm.26019

DO - 10.1002/hbm.26019

M3 - Article

AN - SCOPUS:85134370482

SN - 1065-9471

VL - 43

SP - 5432

EP - 5451

JO - Human Brain Mapping

JF - Human Brain Mapping

IS - 18

ER -