TY - JOUR
T1 - The injured cell
T2 - the role of the dendritic cell system as a sentinel receptor pathway
AU - Ibrahim, Mohammad A.A.
AU - Chain, Benjamin M.
AU - Katz, David R.
N1 - Funding Information:
Studies in our laboratory on rhe role of rhe dendritic cell and macrophages ystemi n tolerancei nductwn are funded by the Arthritis and RheumatismC ouncil, the British Heart Foundation. the Imperial Cancer Research Fund, the Multiple SclerosisS ociety and the Nuffield kxmdation.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1995/4
Y1 - 1995/4
N2 - A major unresolved paradox in immunology remains: how do we avoid harm, despite the abundant opportunities for induction of immune responses against self-proteins? Here, Mohammad Ibrahim, Benjamin Chain and David Katz extend Janeway's proposed explanation, arguing that adaptive immune responses are initiated not only by conserved microbial products, but also by microenvironmental tissue injury. They suggest that the key step is local dendritic cell activation, followed by upregulation of T-cell costimulatory molecules on these cells, and migration, leading to antigen presentation.
AB - A major unresolved paradox in immunology remains: how do we avoid harm, despite the abundant opportunities for induction of immune responses against self-proteins? Here, Mohammad Ibrahim, Benjamin Chain and David Katz extend Janeway's proposed explanation, arguing that adaptive immune responses are initiated not only by conserved microbial products, but also by microenvironmental tissue injury. They suggest that the key step is local dendritic cell activation, followed by upregulation of T-cell costimulatory molecules on these cells, and migration, leading to antigen presentation.
UR - http://www.scopus.com/inward/record.url?scp=0028952299&partnerID=8YFLogxK
U2 - 10.1016/0167-5699(95)80118-9
DO - 10.1016/0167-5699(95)80118-9
M3 - Article
C2 - 7734045
AN - SCOPUS:0028952299
SN - 0167-5699
VL - 16
SP - 181
EP - 186
JO - Immunology Today
JF - Immunology Today
IS - 4
ER -