King's College London

Research portal

The landscape of cancer genes and mutational processes in breast cancer

Research output: Contribution to journalLetterpeer-review

Standard

The landscape of cancer genes and mutational processes in breast cancer. / Stephens, Philip J; Tarpey, Patrick S; Davies, Helen; Van Loo, Peter; Greenman, Chris; Wedge, David C; Nik-Zainal, Serena; Martin, Sancha; Varela, Ignacio; Bignell, Graham R; Yates, Lucy R; Papaemmanuil, Elli; Beare, David; Butler, Adam; Cheverton, Angela; Gamble, John; Hinton, Jonathan; Jia, Mingming; Jayakumar, Alagu; Jones, David; Latimer, Calli; Lau, King Wai; McLaren, Stuart; McBride, David J; Menzies, Andrew; Mudie, Laura; Raine, Keiran; Rad, Roland; Chapman, Michael Spencer; Teague, Jon; Easton, Douglas; Langerød, Anita; Lee, Ming Ta Michael; Shen, Chen-Yang; Tee, Benita Tan Kiat; Huimin, Bernice Wong; Broeks, Annegien; Vargas, Ana Cristina; Turashvili, Gulisa; Martens, John; Fatima, Aquila; Miron, Penelope; Chin, Suet-Feung; Thomas, Gilles; Boyault, Sandrine; Mariani, Odette; Lakhani, Sunil R; van de Vijver, Marc; van 't Veer, Laura; Tutt, Andrew; Oslo Breast Cancer Consortium (OSBREAC).

In: NATURE, Vol. 486, No. 7403, 21.06.2012, p. 400-404.

Research output: Contribution to journalLetterpeer-review

Harvard

Stephens, PJ, Tarpey, PS, Davies, H, Van Loo, P, Greenman, C, Wedge, DC, Nik-Zainal, S, Martin, S, Varela, I, Bignell, GR, Yates, LR, Papaemmanuil, E, Beare, D, Butler, A, Cheverton, A, Gamble, J, Hinton, J, Jia, M, Jayakumar, A, Jones, D, Latimer, C, Lau, KW, McLaren, S, McBride, DJ, Menzies, A, Mudie, L, Raine, K, Rad, R, Chapman, MS, Teague, J, Easton, D, Langerød, A, Lee, MTM, Shen, C-Y, Tee, BTK, Huimin, BW, Broeks, A, Vargas, AC, Turashvili, G, Martens, J, Fatima, A, Miron, P, Chin, S-F, Thomas, G, Boyault, S, Mariani, O, Lakhani, SR, van de Vijver, M, van 't Veer, L, Tutt, A & Oslo Breast Cancer Consortium (OSBREAC) 2012, 'The landscape of cancer genes and mutational processes in breast cancer', NATURE, vol. 486, no. 7403, pp. 400-404. https://doi.org/10.1038/nature11017

APA

Stephens, P. J., Tarpey, P. S., Davies, H., Van Loo, P., Greenman, C., Wedge, D. C., Nik-Zainal, S., Martin, S., Varela, I., Bignell, G. R., Yates, L. R., Papaemmanuil, E., Beare, D., Butler, A., Cheverton, A., Gamble, J., Hinton, J., Jia, M., Jayakumar, A., ... Oslo Breast Cancer Consortium (OSBREAC) (2012). The landscape of cancer genes and mutational processes in breast cancer. NATURE, 486(7403), 400-404. https://doi.org/10.1038/nature11017

Vancouver

Stephens PJ, Tarpey PS, Davies H, Van Loo P, Greenman C, Wedge DC et al. The landscape of cancer genes and mutational processes in breast cancer. NATURE. 2012 Jun 21;486(7403):400-404. https://doi.org/10.1038/nature11017

Author

Stephens, Philip J ; Tarpey, Patrick S ; Davies, Helen ; Van Loo, Peter ; Greenman, Chris ; Wedge, David C ; Nik-Zainal, Serena ; Martin, Sancha ; Varela, Ignacio ; Bignell, Graham R ; Yates, Lucy R ; Papaemmanuil, Elli ; Beare, David ; Butler, Adam ; Cheverton, Angela ; Gamble, John ; Hinton, Jonathan ; Jia, Mingming ; Jayakumar, Alagu ; Jones, David ; Latimer, Calli ; Lau, King Wai ; McLaren, Stuart ; McBride, David J ; Menzies, Andrew ; Mudie, Laura ; Raine, Keiran ; Rad, Roland ; Chapman, Michael Spencer ; Teague, Jon ; Easton, Douglas ; Langerød, Anita ; Lee, Ming Ta Michael ; Shen, Chen-Yang ; Tee, Benita Tan Kiat ; Huimin, Bernice Wong ; Broeks, Annegien ; Vargas, Ana Cristina ; Turashvili, Gulisa ; Martens, John ; Fatima, Aquila ; Miron, Penelope ; Chin, Suet-Feung ; Thomas, Gilles ; Boyault, Sandrine ; Mariani, Odette ; Lakhani, Sunil R ; van de Vijver, Marc ; van 't Veer, Laura ; Tutt, Andrew ; Oslo Breast Cancer Consortium (OSBREAC). / The landscape of cancer genes and mutational processes in breast cancer. In: NATURE. 2012 ; Vol. 486, No. 7403. pp. 400-404.

Bibtex Download

@article{53275598aa4d47c68225af58fedf470f,
title = "The landscape of cancer genes and mutational processes in breast cancer",
abstract = "All cancers carry somatic mutations in their genomes. A subset, known as driver mutations, confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis, and the remainder are passenger mutations. The driver mutations and mutational processes operative in breast cancer have not yet been comprehensively explored. Here we examine the genomes of 100 tumours for somatic copy number changes and mutations in the coding exons of protein-coding genes. The number of somatic mutations varied markedly between individual tumours. We found strong correlations between mutation number, age at which cancer was diagnosed and cancer histological grade, and observed multiple mutational signatures, including one present in about ten per cent of tumours characterized by numerous mutations of cytosine at TpC dinucleotides. Driver mutations were identified in several new cancer genes including AKT2, ARID1B, CASP8, CDKN1B, MAP3K1, MAP3K13, NCOR1, SMARCD1 and TBX3. Among the 100 tumours, we found driver mutations in at least 40 cancer genes and 73 different combinations of mutated cancer genes. The results highlight the substantial genetic diversity underlying this common disease.",
author = "Stephens, {Philip J} and Tarpey, {Patrick S} and Helen Davies and {Van Loo}, Peter and Chris Greenman and Wedge, {David C} and Serena Nik-Zainal and Sancha Martin and Ignacio Varela and Bignell, {Graham R} and Yates, {Lucy R} and Elli Papaemmanuil and David Beare and Adam Butler and Angela Cheverton and John Gamble and Jonathan Hinton and Mingming Jia and Alagu Jayakumar and David Jones and Calli Latimer and Lau, {King Wai} and Stuart McLaren and McBride, {David J} and Andrew Menzies and Laura Mudie and Keiran Raine and Roland Rad and Chapman, {Michael Spencer} and Jon Teague and Douglas Easton and Anita Langer{\o}d and Lee, {Ming Ta Michael} and Chen-Yang Shen and Tee, {Benita Tan Kiat} and Huimin, {Bernice Wong} and Annegien Broeks and Vargas, {Ana Cristina} and Gulisa Turashvili and John Martens and Aquila Fatima and Penelope Miron and Suet-Feung Chin and Gilles Thomas and Sandrine Boyault and Odette Mariani and Lakhani, {Sunil R} and {van de Vijver}, Marc and {van 't Veer}, Laura and Andrew Tutt and {Oslo Breast Cancer Consortium (OSBREAC)}",
year = "2012",
month = jun,
day = "21",
doi = "10.1038/nature11017",
language = "English",
volume = "486",
pages = "400--404",
journal = "NATURE",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7403",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The landscape of cancer genes and mutational processes in breast cancer

AU - Stephens, Philip J

AU - Tarpey, Patrick S

AU - Davies, Helen

AU - Van Loo, Peter

AU - Greenman, Chris

AU - Wedge, David C

AU - Nik-Zainal, Serena

AU - Martin, Sancha

AU - Varela, Ignacio

AU - Bignell, Graham R

AU - Yates, Lucy R

AU - Papaemmanuil, Elli

AU - Beare, David

AU - Butler, Adam

AU - Cheverton, Angela

AU - Gamble, John

AU - Hinton, Jonathan

AU - Jia, Mingming

AU - Jayakumar, Alagu

AU - Jones, David

AU - Latimer, Calli

AU - Lau, King Wai

AU - McLaren, Stuart

AU - McBride, David J

AU - Menzies, Andrew

AU - Mudie, Laura

AU - Raine, Keiran

AU - Rad, Roland

AU - Chapman, Michael Spencer

AU - Teague, Jon

AU - Easton, Douglas

AU - Langerød, Anita

AU - Lee, Ming Ta Michael

AU - Shen, Chen-Yang

AU - Tee, Benita Tan Kiat

AU - Huimin, Bernice Wong

AU - Broeks, Annegien

AU - Vargas, Ana Cristina

AU - Turashvili, Gulisa

AU - Martens, John

AU - Fatima, Aquila

AU - Miron, Penelope

AU - Chin, Suet-Feung

AU - Thomas, Gilles

AU - Boyault, Sandrine

AU - Mariani, Odette

AU - Lakhani, Sunil R

AU - van de Vijver, Marc

AU - van 't Veer, Laura

AU - Tutt, Andrew

AU - Oslo Breast Cancer Consortium (OSBREAC)

PY - 2012/6/21

Y1 - 2012/6/21

N2 - All cancers carry somatic mutations in their genomes. A subset, known as driver mutations, confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis, and the remainder are passenger mutations. The driver mutations and mutational processes operative in breast cancer have not yet been comprehensively explored. Here we examine the genomes of 100 tumours for somatic copy number changes and mutations in the coding exons of protein-coding genes. The number of somatic mutations varied markedly between individual tumours. We found strong correlations between mutation number, age at which cancer was diagnosed and cancer histological grade, and observed multiple mutational signatures, including one present in about ten per cent of tumours characterized by numerous mutations of cytosine at TpC dinucleotides. Driver mutations were identified in several new cancer genes including AKT2, ARID1B, CASP8, CDKN1B, MAP3K1, MAP3K13, NCOR1, SMARCD1 and TBX3. Among the 100 tumours, we found driver mutations in at least 40 cancer genes and 73 different combinations of mutated cancer genes. The results highlight the substantial genetic diversity underlying this common disease.

AB - All cancers carry somatic mutations in their genomes. A subset, known as driver mutations, confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis, and the remainder are passenger mutations. The driver mutations and mutational processes operative in breast cancer have not yet been comprehensively explored. Here we examine the genomes of 100 tumours for somatic copy number changes and mutations in the coding exons of protein-coding genes. The number of somatic mutations varied markedly between individual tumours. We found strong correlations between mutation number, age at which cancer was diagnosed and cancer histological grade, and observed multiple mutational signatures, including one present in about ten per cent of tumours characterized by numerous mutations of cytosine at TpC dinucleotides. Driver mutations were identified in several new cancer genes including AKT2, ARID1B, CASP8, CDKN1B, MAP3K1, MAP3K13, NCOR1, SMARCD1 and TBX3. Among the 100 tumours, we found driver mutations in at least 40 cancer genes and 73 different combinations of mutated cancer genes. The results highlight the substantial genetic diversity underlying this common disease.

U2 - 10.1038/nature11017

DO - 10.1038/nature11017

M3 - Letter

C2 - 22722201

VL - 486

SP - 400

EP - 404

JO - NATURE

JF - NATURE

SN - 0028-0836

IS - 7403

ER -

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454