The melanocortin receptor agonist NDP-MSH impairs the allostimulatory function of dendritic cells

La'Verne P. Rennalls, Thomas Seidl, James M. G. Larkin, Claudia Wellbrock, Martin E. Gore, Tim Eisen, Ludovica Bruno

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    P>As alpha-melanocyte-stimulating hormone (alpha-MSH) is released by immunocompetent cells and has potent immunosuppressive properties, it was determined whether human dendritic cells (DCs) express the receptor for this hormone. Reverse transcription-polymerase chain reaction detected messenger RNA specific for all of the known melanocortin receptors in DCs. Mixed lymphocyte reactions also revealed that treatment with [Nle4, DPhe7]-alpha-MSH (NDP-MSH), a potent alpha-MSH analogue, significantly reduced the ability of DCs to stimulate allogeneic T cells. The expression of various cell surface adhesion, maturation and costimulatory molecules on DCs was also investigated. Although treatment with NDP-MSH did not alter the expression of CD83 and major histocompatibility complex class and , the surface expression of CD86 (B7.2), intercellular adhesion molecule (ICAM-1/CD54) and CD1a was reduced. In summary, our data indicate that NDP-MSH inhibits the functional activity of DCs, possibly by down-regulating antigen-presenting and adhesion molecules and that these events may be mediated via the extracellular signal-regulated kinase 1 and 2 pathway.
    Original languageEnglish
    Pages (from-to)610 - 619
    Number of pages10
    JournalImmunology
    Volume129
    Issue number4
    DOIs
    Publication statusPublished - Apr 2010

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