The molecular genetics of Huntington disease - a history.

TY - JOUR

T1 - The molecular genetics of Huntington disease - a history.

AU - Bates, G P

PY - 2005/10

Y1 - 2005/10

N2 - The Huntington disease gene was mapped to human chromosome 4p in 1983 and 10 years later the pathogenic mutation was identified as a CAG-repeat expansion. Our current understanding of the molecular pathogenesis of Huntington disease could never have been achieved without the recent progress in the field of molecular genetics. We are now equipped with powerful genetic models that continue to uncover new aspects of the pathogenesis of Huntington disease and will be instrumental for the development of therapeutic approaches for this disease

AB - The Huntington disease gene was mapped to human chromosome 4p in 1983 and 10 years later the pathogenic mutation was identified as a CAG-repeat expansion. Our current understanding of the molecular pathogenesis of Huntington disease could never have been achieved without the recent progress in the field of molecular genetics. We are now equipped with powerful genetic models that continue to uncover new aspects of the pathogenesis of Huntington disease and will be instrumental for the development of therapeutic approaches for this disease

U2 - 10.1038/nrg1686

DO - 10.1038/nrg1686

M3 - Literature review

VL - 6

SP - 766

EP - 773

JO - NATURE REVIEWS GENETICS

JF - NATURE REVIEWS GENETICS

IS - 10

ER -