The Myelodysplastic syndromes: A matter of life or death

TY - JOUR

T1 - The Myelodysplastic syndromes: A matter of life or death

AU - Parker, J E

AU - Mufti, G J

PY - 2003

Y1 - 2003

N2 - Apoptosis is upregulated in early myelodysplastic syndromes (MDS) and may contribute to the peripheral cytopenias commonly observed. Conversely, leukemic progression is associated with abrogation of programmed cell death (PCD). The stage of hematopoietic cell maturation at which defects in PCD arise and the underlying causes of apoptosis dysregulation remain unknown. This paper outlines the apoptotic process in normal hematopoietic cells and summarizes current data regarding the role, potential causes and clinical implications of altered apoptosis in MDS. Copyright (C) 2004 S. Karger AG, Basel.

AB - Apoptosis is upregulated in early myelodysplastic syndromes (MDS) and may contribute to the peripheral cytopenias commonly observed. Conversely, leukemic progression is associated with abrogation of programmed cell death (PCD). The stage of hematopoietic cell maturation at which defects in PCD arise and the underlying causes of apoptosis dysregulation remain unknown. This paper outlines the apoptotic process in normal hematopoietic cells and summarizes current data regarding the role, potential causes and clinical implications of altered apoptosis in MDS. Copyright (C) 2004 S. Karger AG, Basel.

U2 - 10.1159/000074488

DO - 10.1159/000074488

M3 - Literature review

VL - 111

SP - 78

EP - 99

JO - Acta Haematologica

JF - Acta Haematologica

IS - 1-2

ER -