The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens

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Abstract

The Network of Cancer Genes (NCG) is a manually curated repository of 2372 genes whose somatic modifications have known or predicted cancer driver roles. These genes were collected from 275 publications, including two sources of known cancer genes and 273 cancer sequencing screens of more than 100 cancer types from 34,905 cancer donors and multiple primary sites. This represents a more than 1.5-fold content increase compared to the previous version. NCG also annotates properties of cancer genes, such as duplicability, evolutionary origin, RNA and protein expression, miRNA and protein interactions, and protein function and essentiality. NCG is accessible at http://ncg.kcl.ac.uk/ .

Original languageEnglish
Article number1
Number of pages11
JournalGenome Biology
Volume20
Issue number1
Early online date3 Jan 2019
DOIs
Publication statusPublished - 3 Jan 2019

Keywords

  • Cancer genes
  • Cancer genomics screens
  • Cancer heterogeneity
  • Systems-level properties

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