@article{d75c23de98e94cad92b45094ed9a5909,
title = "The network structure of mania symptoms differs between people with and without binge eating",
abstract = "OBJECTIVES: People with bipolar disorder who also report binge eating have increased psychopathology and greater impairment than those without binge eating. Whether this co-occurrence is related to binge eating as a symptom or presents differently across full-syndrome eating disorders with binge eating is unclear.METHODS: We first compared networks of 13 lifetime mania symptoms in 34,226 participants from the United Kingdom's National Institute for Health and Care Research BioResource with (n = 12,104) and without (n = 22,122) lifetime binge eating. Second, in the subsample with binge eating, we compared networks of mania symptoms in participants with lifetime anorexia nervosa binge-eating/purging (n = 825), bulimia nervosa (n = 3737), and binge-eating disorder (n = 3648).RESULTS: People with binge eating endorsed every mania symptom significantly more often than those without binge eating. Within the subsample, people with bulimia nervosa most often had the highest endorsement rate of each mania symptom. We found significant differences in network parameter statistics, including network structure (M = 0.25, p = 0.001) and global strength (S = 1.84, p = 0.002) when comparing the binge eating with no binge-eating participants. However, network structure differences were sensitive to reductions in sample size and the greater density of the latter network was explained by the large proportion of participants (34%) without mania symptoms. The structure of the anorexia nervosa binge-eating/purging network differed from the bulimia nervosa network (M = 0.66, p = 0.001), but the result was unstable.CONCLUSIONS: Our results suggest that the presence and structure of mania symptoms may be more associated with binge eating as a symptom rather than any specific binge-type eating disorder. Further research with larger sample sizes is required to confirm our findings.",
author = "Davies, {Helena L} and Peel, {Alicia J} and Jessica Mundy and Dina Monssen and Saakshi Kakar and Davies, {Molly R} and Adey, {Brett N} and Ch{\'e}rie Armour and Gursharan Kalsi and Yuhao Lin and Ian Marsh and Rogers, {Henry C} and Walters, {James T R} and Moritz Herle and Kiran Glen and Malouf, {Chelsea Mika} and Kelly, {Emily J} and Eley, {Thalia C} and Janet Treasure and Gerome Breen and Christopher H{\"u}bel",
note = "{\textcopyright} 2023 The Authors. Bipolar Disorders published by John Wiley & Sons Ltd. Funding Information: This work was supported by the National Institute for Health and Care Research (NIHR) BioResource (RG94028, RG85445), NIHR Biomedical Research Centre (IS‐BRC‐1215‐20018), HSC R&D Division, Public Health Agency (COM/5516/18), MRC Mental Health Data Pathfinder Award (MC_PC_17217), and the National Centre for Mental Health funding through Health and Care Research Wales. Prof Eley and Prof Breen are part‐funded by a program grant from the UK Medical Research Council (MR/V012878/1). Helena Davies and Alicia Peel acknowledge funding from the Economic and Social Research Council (ESRC) as part of a PhD studentship. Dr H{\"u}bel acknowledges funding from Lundbeckfonden (R276‐2018‐4581). Dr Herle is funded by a fellowship from the Medical Research Council UK (MR/T027843/1). Jessica Mundy acknowledges funding from the Lord Leverhulme Charitable Grant. Brett N. Adey acknowledges funding through a Pre‐doctoral Fellowship from the NIHR (NIHR301067). Funding Information: Prof Breen has received honoraria, research or conference grants and consulting fees from Illumina, Otsuka, and COMPASS Pathfinder Ltd. Prof Walters has received grant funding from Takeda for work unrelated to the GLAD Study. The remaining authors have nothing to disclose. Publisher Copyright: {\textcopyright} 2023 The Authors. Bipolar Disorders published by John Wiley & Sons Ltd.",
year = "2023",
month = jun,
day = "12",
doi = "10.1111/bdi.13355",
language = "English",
journal = "Bipolar Disorders",
issn = "1398-5647",
publisher = "Blackwell Munksgaard",
}