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The neural mechanisms of social reward in early psychosis

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The neural mechanisms of social reward in early psychosis. / Fett, Anne Kathrin J.; Mouchlianitis, Elias; Gromann, Paula M.; Vanes, Lucy; Shergill, Sukhi S.; Krabbendam, Lydia.

In: Social Cognitive and Affective Neuroscience, Vol. 14, No. 8, 31.08.2019, p. 861-870.

Research output: Contribution to journalArticle

Harvard

Fett, AKJ, Mouchlianitis, E, Gromann, PM, Vanes, L, Shergill, SS & Krabbendam, L 2019, 'The neural mechanisms of social reward in early psychosis', Social Cognitive and Affective Neuroscience, vol. 14, no. 8, pp. 861-870. https://doi.org/10.1093/scan/nsz058

APA

Fett, A. K. J., Mouchlianitis, E., Gromann, P. M., Vanes, L., Shergill, S. S., & Krabbendam, L. (2019). The neural mechanisms of social reward in early psychosis. Social Cognitive and Affective Neuroscience, 14(8), 861-870. https://doi.org/10.1093/scan/nsz058

Vancouver

Fett AKJ, Mouchlianitis E, Gromann PM, Vanes L, Shergill SS, Krabbendam L. The neural mechanisms of social reward in early psychosis. Social Cognitive and Affective Neuroscience. 2019 Aug 31;14(8):861-870. https://doi.org/10.1093/scan/nsz058

Author

Fett, Anne Kathrin J. ; Mouchlianitis, Elias ; Gromann, Paula M. ; Vanes, Lucy ; Shergill, Sukhi S. ; Krabbendam, Lydia. / The neural mechanisms of social reward in early psychosis. In: Social Cognitive and Affective Neuroscience. 2019 ; Vol. 14, No. 8. pp. 861-870.

Bibtex Download

@article{3f4a3a75e1c940bc944f8eb1d1a4ec86,
title = "The neural mechanisms of social reward in early psychosis",
abstract = "In chronic psychosis, reduced trust is associated with a neural insensitivity to social reward and reduced theory of mind (ToM). Here we investigate whether these mechanisms could underlie emerging social impairments in early psychosis. Twenty-two participants with early psychosis and 25 controls (male, 13-19 years) participated in two interactive trust games against a cooperative and unfair partner. Region of interest neuroimaging analyses included right caudate, medial prefrontal cortex (mPFC) and right temporoparietal junction (rTPJ), involved in reward and ToM processing. Both groups showed similar levels of trust (i.e. investments). However, individuals with psychosis failed to activate the caudate differentially in response to cooperation and unfairness while making decisions to trust. During cooperative returns, patients showed reduced and controls increased caudate activation. Patients demonstrated greater rTPJ activation than controls, possibly pointing towards compensatory mechanisms. Effects were associated with Wechsler Abbreviated Scale of Intelligence vocabulary scores. No group differences emerged in mPFC activation. Early psychosis is associated with an aberrant neural sensitivity to social reward. This could foster reduced social motivation and social isolation. Absent behavioural differences in early, relative to chronic psychosis could indicate that trust is achieved through increased compensatory demand on ToM.",
keywords = "adolescence, early psychosis, fMRI, neuroeconomics, social cognition, trust",
author = "Fett, {Anne Kathrin J.} and Elias Mouchlianitis and Gromann, {Paula M.} and Lucy Vanes and Shergill, {Sukhi S.} and Lydia Krabbendam",
year = "2019",
month = "8",
day = "31",
doi = "10.1093/scan/nsz058",
language = "English",
volume = "14",
pages = "861--870",
journal = "Social Cognitive and Affective Neuroscience",
issn = "1749-5016",
publisher = "OXFORD UNIV PRESS",
number = "8",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The neural mechanisms of social reward in early psychosis

AU - Fett, Anne Kathrin J.

AU - Mouchlianitis, Elias

AU - Gromann, Paula M.

AU - Vanes, Lucy

AU - Shergill, Sukhi S.

AU - Krabbendam, Lydia

PY - 2019/8/31

Y1 - 2019/8/31

N2 - In chronic psychosis, reduced trust is associated with a neural insensitivity to social reward and reduced theory of mind (ToM). Here we investigate whether these mechanisms could underlie emerging social impairments in early psychosis. Twenty-two participants with early psychosis and 25 controls (male, 13-19 years) participated in two interactive trust games against a cooperative and unfair partner. Region of interest neuroimaging analyses included right caudate, medial prefrontal cortex (mPFC) and right temporoparietal junction (rTPJ), involved in reward and ToM processing. Both groups showed similar levels of trust (i.e. investments). However, individuals with psychosis failed to activate the caudate differentially in response to cooperation and unfairness while making decisions to trust. During cooperative returns, patients showed reduced and controls increased caudate activation. Patients demonstrated greater rTPJ activation than controls, possibly pointing towards compensatory mechanisms. Effects were associated with Wechsler Abbreviated Scale of Intelligence vocabulary scores. No group differences emerged in mPFC activation. Early psychosis is associated with an aberrant neural sensitivity to social reward. This could foster reduced social motivation and social isolation. Absent behavioural differences in early, relative to chronic psychosis could indicate that trust is achieved through increased compensatory demand on ToM.

AB - In chronic psychosis, reduced trust is associated with a neural insensitivity to social reward and reduced theory of mind (ToM). Here we investigate whether these mechanisms could underlie emerging social impairments in early psychosis. Twenty-two participants with early psychosis and 25 controls (male, 13-19 years) participated in two interactive trust games against a cooperative and unfair partner. Region of interest neuroimaging analyses included right caudate, medial prefrontal cortex (mPFC) and right temporoparietal junction (rTPJ), involved in reward and ToM processing. Both groups showed similar levels of trust (i.e. investments). However, individuals with psychosis failed to activate the caudate differentially in response to cooperation and unfairness while making decisions to trust. During cooperative returns, patients showed reduced and controls increased caudate activation. Patients demonstrated greater rTPJ activation than controls, possibly pointing towards compensatory mechanisms. Effects were associated with Wechsler Abbreviated Scale of Intelligence vocabulary scores. No group differences emerged in mPFC activation. Early psychosis is associated with an aberrant neural sensitivity to social reward. This could foster reduced social motivation and social isolation. Absent behavioural differences in early, relative to chronic psychosis could indicate that trust is achieved through increased compensatory demand on ToM.

KW - adolescence

KW - early psychosis

KW - fMRI

KW - neuroeconomics

KW - social cognition

KW - trust

UR - http://www.scopus.com/inward/record.url?scp=85074875237&partnerID=8YFLogxK

U2 - 10.1093/scan/nsz058

DO - 10.1093/scan/nsz058

M3 - Article

C2 - 31506672

AN - SCOPUS:85074875237

VL - 14

SP - 861

EP - 870

JO - Social Cognitive and Affective Neuroscience

JF - Social Cognitive and Affective Neuroscience

SN - 1749-5016

IS - 8

ER -

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