THE NEURONAL CELL CYCLE AS A MECHANISM OF PATHOGENESIS IN ALZHEIMER'S DISEASE

Antonio Currais, Bilal Malik, Tibor Hortobagyi, Salvador Soriano

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Differentiated neurons display specific biochemical, physiological and morphological properties that apparently prevent them from further cell division. Nevertheless, expression of cell cycle modulators persists after neuronal differentiation and is upregulated under stress conditions, such as trophic factor deprivation, oxidative stress and the presence of DNA damaging agents. This apparent reactivation of the cell cycle has been postulated as a sine qua non for neuronal death in response to those stress conditions, particularly in Alzheimer's disease. However, the physiological and pathogenic implications of a putative neuronal cell cycle are far from clear. Here, we discuss the notion of the neuronal cell cycle as a mediator of cell death in Alzheimer's disease.
    Original languageEnglish
    Pages (from-to)II13 - II20
    JournalZdravniski Vestnik-Slovenian Medical Journal
    Volume77
    Publication statusPublished - 2008

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