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The neuroscience of sadness: A multidisciplinary synthesis and collaborative review

Research output: Contribution to journalReview article

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The neuroscience of sadness : A multidisciplinary synthesis and collaborative review. / Arias, Juan A.; Williams, Claire; Raghvani, Rashmi; Aghajani, Moji; Baez, Sandra; Belzung, Catherine; Booij, Linda; Busatto, Geraldo; Chiarella, Julian; Fu, Cynthia HY; Ibanez, Agustin; Liddell, Belinda J.; Lowe, Leroy; Penninx, Brenda W.J.H.; Rosa, Pedro; Kemp, Andrew H.

In: Neuroscience and Biobehavioral Reviews, Vol. 111, 01.04.2020, p. 199-228.

Research output: Contribution to journalReview article

Harvard

Arias, JA, Williams, C, Raghvani, R, Aghajani, M, Baez, S, Belzung, C, Booij, L, Busatto, G, Chiarella, J, Fu, CHY, Ibanez, A, Liddell, BJ, Lowe, L, Penninx, BWJH, Rosa, P & Kemp, AH 2020, 'The neuroscience of sadness: A multidisciplinary synthesis and collaborative review', Neuroscience and Biobehavioral Reviews, vol. 111, pp. 199-228. https://doi.org/10.1016/j.neubiorev.2020.01.006

APA

Arias, J. A., Williams, C., Raghvani, R., Aghajani, M., Baez, S., Belzung, C., ... Kemp, A. H. (2020). The neuroscience of sadness: A multidisciplinary synthesis and collaborative review. Neuroscience and Biobehavioral Reviews, 111, 199-228. https://doi.org/10.1016/j.neubiorev.2020.01.006

Vancouver

Arias JA, Williams C, Raghvani R, Aghajani M, Baez S, Belzung C et al. The neuroscience of sadness: A multidisciplinary synthesis and collaborative review. Neuroscience and Biobehavioral Reviews. 2020 Apr 1;111:199-228. https://doi.org/10.1016/j.neubiorev.2020.01.006

Author

Arias, Juan A. ; Williams, Claire ; Raghvani, Rashmi ; Aghajani, Moji ; Baez, Sandra ; Belzung, Catherine ; Booij, Linda ; Busatto, Geraldo ; Chiarella, Julian ; Fu, Cynthia HY ; Ibanez, Agustin ; Liddell, Belinda J. ; Lowe, Leroy ; Penninx, Brenda W.J.H. ; Rosa, Pedro ; Kemp, Andrew H. / The neuroscience of sadness : A multidisciplinary synthesis and collaborative review. In: Neuroscience and Biobehavioral Reviews. 2020 ; Vol. 111. pp. 199-228.

Bibtex Download

@article{f3aeb984471746f29c92dc0d38774c44,
title = "The neuroscience of sadness: A multidisciplinary synthesis and collaborative review",
abstract = "Sadness is typically characterized by raised inner eyebrows, lowered corners of the mouth, reduced walking speed, and slumped posture. Ancient subcortical circuitry provides a neuroanatomical foundation, extending from dorsal periaqueductal grey to subgenual anterior cingulate, the latter of which is now a treatment target in disorders of sadness. Electrophysiological studies further emphasize a role for reduced left relative to right frontal asymmetry in sadness, underpinning interest in the transcranial stimulation of left dorsolateral prefrontal cortex as an antidepressant target. Neuroimaging studies – including meta-analyses – indicate that sadness is associated with reduced cortical activation, which may contribute to reduced parasympathetic inhibitory control over medullary cardioacceleratory circuits. Reduced cardiac control may – in part – contribute to epidemiological reports of reduced life expectancy in affective disorders, effects equivalent to heavy smoking. We suggest that the field may be moving toward a theoretical consensus, in which different models relating to basic emotion theory and psychological constructionism may be considered as complementary, working at different levels of the phylogenetic hierarchy.",
keywords = "Affective neuroscience, Basic emotions, Genetics, GENIAL model, Health and wellbeing, Heart rate variability, Major depressive disorder, Neuroimaging, Psychological constructionism, Psychophysiology, Sadness, Vagal function",
author = "Arias, {Juan A.} and Claire Williams and Rashmi Raghvani and Moji Aghajani and Sandra Baez and Catherine Belzung and Linda Booij and Geraldo Busatto and Julian Chiarella and Fu, {Cynthia HY} and Agustin Ibanez and Liddell, {Belinda J.} and Leroy Lowe and Penninx, {Brenda W.J.H.} and Pedro Rosa and Kemp, {Andrew H.}",
year = "2020",
month = "4",
day = "1",
doi = "10.1016/j.neubiorev.2020.01.006",
language = "English",
volume = "111",
pages = "199--228",
journal = "Neuroscience and Biobehavioral Reviews",
issn = "0149-7634",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The neuroscience of sadness

T2 - A multidisciplinary synthesis and collaborative review

AU - Arias, Juan A.

AU - Williams, Claire

AU - Raghvani, Rashmi

AU - Aghajani, Moji

AU - Baez, Sandra

AU - Belzung, Catherine

AU - Booij, Linda

AU - Busatto, Geraldo

AU - Chiarella, Julian

AU - Fu, Cynthia HY

AU - Ibanez, Agustin

AU - Liddell, Belinda J.

AU - Lowe, Leroy

AU - Penninx, Brenda W.J.H.

AU - Rosa, Pedro

AU - Kemp, Andrew H.

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Sadness is typically characterized by raised inner eyebrows, lowered corners of the mouth, reduced walking speed, and slumped posture. Ancient subcortical circuitry provides a neuroanatomical foundation, extending from dorsal periaqueductal grey to subgenual anterior cingulate, the latter of which is now a treatment target in disorders of sadness. Electrophysiological studies further emphasize a role for reduced left relative to right frontal asymmetry in sadness, underpinning interest in the transcranial stimulation of left dorsolateral prefrontal cortex as an antidepressant target. Neuroimaging studies – including meta-analyses – indicate that sadness is associated with reduced cortical activation, which may contribute to reduced parasympathetic inhibitory control over medullary cardioacceleratory circuits. Reduced cardiac control may – in part – contribute to epidemiological reports of reduced life expectancy in affective disorders, effects equivalent to heavy smoking. We suggest that the field may be moving toward a theoretical consensus, in which different models relating to basic emotion theory and psychological constructionism may be considered as complementary, working at different levels of the phylogenetic hierarchy.

AB - Sadness is typically characterized by raised inner eyebrows, lowered corners of the mouth, reduced walking speed, and slumped posture. Ancient subcortical circuitry provides a neuroanatomical foundation, extending from dorsal periaqueductal grey to subgenual anterior cingulate, the latter of which is now a treatment target in disorders of sadness. Electrophysiological studies further emphasize a role for reduced left relative to right frontal asymmetry in sadness, underpinning interest in the transcranial stimulation of left dorsolateral prefrontal cortex as an antidepressant target. Neuroimaging studies – including meta-analyses – indicate that sadness is associated with reduced cortical activation, which may contribute to reduced parasympathetic inhibitory control over medullary cardioacceleratory circuits. Reduced cardiac control may – in part – contribute to epidemiological reports of reduced life expectancy in affective disorders, effects equivalent to heavy smoking. We suggest that the field may be moving toward a theoretical consensus, in which different models relating to basic emotion theory and psychological constructionism may be considered as complementary, working at different levels of the phylogenetic hierarchy.

KW - Affective neuroscience

KW - Basic emotions

KW - Genetics

KW - GENIAL model

KW - Health and wellbeing

KW - Heart rate variability

KW - Major depressive disorder

KW - Neuroimaging

KW - Psychological constructionism

KW - Psychophysiology

KW - Sadness

KW - Vagal function

UR - http://www.scopus.com/inward/record.url?scp=85078664197&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2020.01.006

DO - 10.1016/j.neubiorev.2020.01.006

M3 - Review article

C2 - 32001274

AN - SCOPUS:85078664197

VL - 111

SP - 199

EP - 228

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

ER -

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