The nexus between redox state and intermediary metabolism

Anna Zoccarato, Adam A. Nabeebaccus, Rafael R. Oexner, Celio X.C. Santos, Ajay M. Shah*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Reactive oxygen species (ROS) are not just a by-product of cellular metabolic processes but act as signalling molecules that regulate both physiological and pathophysiological processes. A close connection exists in cells between redox homeostasis and cellular metabolism. In this review, we describe how intracellular redox state and glycolytic intermediary metabolism are closely coupled. On the one hand, ROS signalling can control glycolytic intermediary metabolism by direct regulation of the activity of key metabolic enzymes and indirect regulation via redox-sensitive transcription factors. On the other hand, metabolic adaptation and reprogramming in response to physiological or pathological stimuli regulate intracellular redox balance, through mechanisms such as the generation of reducing equivalents. We also discuss the impact of these intermediary metabolism–redox circuits in physiological and disease settings across different tissues. A better understanding of the mechanisms regulating these intermediary metabolism–redox circuits will be crucial to the development of novel therapeutic strategies.

Original languageEnglish
JournalFEBS Journal
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • anabolism
  • intermediary metabolism
  • reactive oxygen species
  • redox
  • warburg effect

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