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The “nuclear physics” behind epigenetic control of cell fate

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The “nuclear physics” behind epigenetic control of cell fate. / Zijl, Sebastiaan; Lomakin, Alexis J.

In: Experimental Cell Research, Vol. 376, No. 2, 15.03.2019, p. 236-239.

Research output: Contribution to journalReview article

Harvard

Zijl, S & Lomakin, AJ 2019, 'The “nuclear physics” behind epigenetic control of cell fate', Experimental Cell Research, vol. 376, no. 2, pp. 236-239. https://doi.org/10.1016/j.yexcr.2019.01.007

APA

Zijl, S., & Lomakin, A. J. (2019). The “nuclear physics” behind epigenetic control of cell fate. Experimental Cell Research, 376(2), 236-239. https://doi.org/10.1016/j.yexcr.2019.01.007

Vancouver

Zijl S, Lomakin AJ. The “nuclear physics” behind epigenetic control of cell fate. Experimental Cell Research. 2019 Mar 15;376(2):236-239. https://doi.org/10.1016/j.yexcr.2019.01.007

Author

Zijl, Sebastiaan ; Lomakin, Alexis J. / The “nuclear physics” behind epigenetic control of cell fate. In: Experimental Cell Research. 2019 ; Vol. 376, No. 2. pp. 236-239.

Bibtex Download

@article{92452643f3d641cd913659602a908c4b,
title = "The “nuclear physics” behind epigenetic control of cell fate",
abstract = "It is well understood that replicative and transcriptional responses in the nucleus occur under the influence of specific extracellular biochemical signals (e.g. growth factors and cytokines). However, it has become apparent recently that the nucleus is also able to sense and respond to more generic cues, such as physical forces and mechanical constraints. Indeed, being the largest and stiffest intracellular organelle, the nucleus is exposed to various types of forces acting from inside and outside the cell. These forces result in global and local deformations of the nucleus, which can significantly affect spatial organization and mechanical state of the nuclear envelope (NE). Considering that peripheral chromatin is attached to the NE, forces applied to the NE are transmitted to chromatin. This, in turn, can impact chromatin organization, dynamics, and activity. Where do these forces originate from and what are the physiological contexts in which they modulate critical nuclear activities? Discussing these questions is the main goal of the present mini-review.",
keywords = "Cell fate, Gene expression, Mechanotransduction, Nuclear deformation",
author = "Sebastiaan Zijl and Lomakin, {Alexis J.}",
year = "2019",
month = "3",
day = "15",
doi = "10.1016/j.yexcr.2019.01.007",
language = "English",
volume = "376",
pages = "236--239",
journal = "Experimental Cell Research",
issn = "0014-4827",
publisher = "ACADEMIC PRESS INC",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The “nuclear physics” behind epigenetic control of cell fate

AU - Zijl, Sebastiaan

AU - Lomakin, Alexis J.

PY - 2019/3/15

Y1 - 2019/3/15

N2 - It is well understood that replicative and transcriptional responses in the nucleus occur under the influence of specific extracellular biochemical signals (e.g. growth factors and cytokines). However, it has become apparent recently that the nucleus is also able to sense and respond to more generic cues, such as physical forces and mechanical constraints. Indeed, being the largest and stiffest intracellular organelle, the nucleus is exposed to various types of forces acting from inside and outside the cell. These forces result in global and local deformations of the nucleus, which can significantly affect spatial organization and mechanical state of the nuclear envelope (NE). Considering that peripheral chromatin is attached to the NE, forces applied to the NE are transmitted to chromatin. This, in turn, can impact chromatin organization, dynamics, and activity. Where do these forces originate from and what are the physiological contexts in which they modulate critical nuclear activities? Discussing these questions is the main goal of the present mini-review.

AB - It is well understood that replicative and transcriptional responses in the nucleus occur under the influence of specific extracellular biochemical signals (e.g. growth factors and cytokines). However, it has become apparent recently that the nucleus is also able to sense and respond to more generic cues, such as physical forces and mechanical constraints. Indeed, being the largest and stiffest intracellular organelle, the nucleus is exposed to various types of forces acting from inside and outside the cell. These forces result in global and local deformations of the nucleus, which can significantly affect spatial organization and mechanical state of the nuclear envelope (NE). Considering that peripheral chromatin is attached to the NE, forces applied to the NE are transmitted to chromatin. This, in turn, can impact chromatin organization, dynamics, and activity. Where do these forces originate from and what are the physiological contexts in which they modulate critical nuclear activities? Discussing these questions is the main goal of the present mini-review.

KW - Cell fate

KW - Gene expression

KW - Mechanotransduction

KW - Nuclear deformation

UR - http://www.scopus.com/inward/record.url?scp=85061262061&partnerID=8YFLogxK

U2 - 10.1016/j.yexcr.2019.01.007

DO - 10.1016/j.yexcr.2019.01.007

M3 - Review article

C2 - 30633879

AN - SCOPUS:85061262061

VL - 376

SP - 236

EP - 239

JO - Experimental Cell Research

JF - Experimental Cell Research

SN - 0014-4827

IS - 2

ER -

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