The Objective Assessment of Cough Frequency in Bronchiectasis

Arietta Spinou; Kai K. Lee; Aish Sinha; Caroline Elston; Michael R. Loebinger; Robert Wilson; Kian Fan Chung; Nadia Yousaf; Ian D. Pavord; Sergio Matos; Rachel Garrod; Surinder S. Birring

doi:10.1007/s00408-017-0038-x

The Objective Assessment of Cough Frequency in Bronchiectasis

Arietta Spinou, Kai K. Lee, Aish Sinha, Caroline Elston, Michael R. Loebinger, Robert Wilson, Kian Fan Chung, Nadia Yousaf, Ian D. Pavord, Sergio Matos, Rachel Garrod, Surinder S. Birring^*

^*Corresponding author for this work

Population Health Sciences

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

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Abstract

Introduction: Cough in bronchiectasis is associated with significant impairment in health status. This study aimed to quantify cough frequency objectively with a cough monitor and investigate its relationship with health status. A secondary aim was to identify clinical predictors of cough frequency. Methods: Fifty-four patients with bronchiectasis were compared with thirty-five healthy controls. Objective 24-h cough, health status (cough-specific: Leicester Cough Questionnaire LCQ and bronchiectasis specific: Bronchiectasis Health Questionnaire BHQ), cough severity and lung function were measured. The clinical predictors of cough frequency in bronchiectasis were determined in a multivariate analysis. Results: Objective cough frequency was significantly raised in patients with bronchiectasis compared to healthy controls [geometric mean (standard deviation)] 184.5 (4.0) vs. 20.6 (3.2) coughs/24-h; mean fold-difference (95% confidence interval) 8.9 (5.2, 15.2); p < 0.001 and they had impaired health status. There was a significant correlation between objective cough frequency and subjective measures; LCQ r = −0.52 and BHQ r = −0.62, both p < 0.001. Sputum production, exacerbations (between past 2 weeks to 12 months) and age were significantly associated with objective cough frequency in multivariate analysis, explaining 52% of the variance (p < 0.001). There was no statistically significant association between cough frequency and lung function. Conclusions: Cough is a common and significant symptom in patients with bronchiectasis. Sputum production, exacerbations and age, but not lung function, were independent predictors of cough frequency. Ambulatory objective cough monitoring provides novel insights and should be further investigated as an outcome measure in bronchiectasis.

Original language	English
Pages (from-to)	575-585
Number of pages	11
Journal	Lung
Volume	195
Issue number	5
Early online date	13 Jul 2017
DOIs	https://doi.org/10.1007/s00408-017-0038-x
Publication status	Published - 1 Oct 2017

Keywords

Bronchiectasis
Bronchiectasis Health Questionnaire
Cough frequency
Leicester cough monitor
Visual analogue scale

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The Objective Assessment of Cough_SPINOU_Firstpublished13July2017_GOLD VoR_CC BYFinal published version, 468 KBLicence: CC BY

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@article{ee487a5b309b4b64a4e7b8052cc914b0,

title = "The Objective Assessment of Cough Frequency in Bronchiectasis",

abstract = "Introduction: Cough in bronchiectasis is associated with significant impairment in health status. This study aimed to quantify cough frequency objectively with a cough monitor and investigate its relationship with health status. A secondary aim was to identify clinical predictors of cough frequency. Methods: Fifty-four patients with bronchiectasis were compared with thirty-five healthy controls. Objective 24-h cough, health status (cough-specific: Leicester Cough Questionnaire LCQ and bronchiectasis specific: Bronchiectasis Health Questionnaire BHQ), cough severity and lung function were measured. The clinical predictors of cough frequency in bronchiectasis were determined in a multivariate analysis. Results: Objective cough frequency was significantly raised in patients with bronchiectasis compared to healthy controls [geometric mean (standard deviation)] 184.5 (4.0) vs. 20.6 (3.2) coughs/24-h; mean fold-difference (95% confidence interval) 8.9 (5.2, 15.2); p < 0.001 and they had impaired health status. There was a significant correlation between objective cough frequency and subjective measures; LCQ r = −0.52 and BHQ r = −0.62, both p < 0.001. Sputum production, exacerbations (between past 2 weeks to 12 months) and age were significantly associated with objective cough frequency in multivariate analysis, explaining 52% of the variance (p < 0.001). There was no statistically significant association between cough frequency and lung function. Conclusions: Cough is a common and significant symptom in patients with bronchiectasis. Sputum production, exacerbations and age, but not lung function, were independent predictors of cough frequency. Ambulatory objective cough monitoring provides novel insights and should be further investigated as an outcome measure in bronchiectasis.",

keywords = "Bronchiectasis, Bronchiectasis Health Questionnaire, Cough frequency, Leicester cough monitor, Visual analogue scale",

author = "Arietta Spinou and Lee, {Kai K.} and Aish Sinha and Caroline Elston and Loebinger, {Michael R.} and Robert Wilson and Chung, {Kian Fan} and Nadia Yousaf and Pavord, {Ian D.} and Sergio Matos and Rachel Garrod and Birring, {Surinder S.}",

year = "2017",

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doi = "10.1007/s00408-017-0038-x",

language = "English",

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journal = "Lung",

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T1 - The Objective Assessment of Cough Frequency in Bronchiectasis

AU - Spinou, Arietta

AU - Lee, Kai K.

AU - Sinha, Aish

AU - Elston, Caroline

AU - Loebinger, Michael R.

AU - Wilson, Robert

AU - Chung, Kian Fan

AU - Yousaf, Nadia

AU - Pavord, Ian D.

AU - Matos, Sergio

AU - Garrod, Rachel

AU - Birring, Surinder S.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Introduction: Cough in bronchiectasis is associated with significant impairment in health status. This study aimed to quantify cough frequency objectively with a cough monitor and investigate its relationship with health status. A secondary aim was to identify clinical predictors of cough frequency. Methods: Fifty-four patients with bronchiectasis were compared with thirty-five healthy controls. Objective 24-h cough, health status (cough-specific: Leicester Cough Questionnaire LCQ and bronchiectasis specific: Bronchiectasis Health Questionnaire BHQ), cough severity and lung function were measured. The clinical predictors of cough frequency in bronchiectasis were determined in a multivariate analysis. Results: Objective cough frequency was significantly raised in patients with bronchiectasis compared to healthy controls [geometric mean (standard deviation)] 184.5 (4.0) vs. 20.6 (3.2) coughs/24-h; mean fold-difference (95% confidence interval) 8.9 (5.2, 15.2); p < 0.001 and they had impaired health status. There was a significant correlation between objective cough frequency and subjective measures; LCQ r = −0.52 and BHQ r = −0.62, both p < 0.001. Sputum production, exacerbations (between past 2 weeks to 12 months) and age were significantly associated with objective cough frequency in multivariate analysis, explaining 52% of the variance (p < 0.001). There was no statistically significant association between cough frequency and lung function. Conclusions: Cough is a common and significant symptom in patients with bronchiectasis. Sputum production, exacerbations and age, but not lung function, were independent predictors of cough frequency. Ambulatory objective cough monitoring provides novel insights and should be further investigated as an outcome measure in bronchiectasis.

AB - Introduction: Cough in bronchiectasis is associated with significant impairment in health status. This study aimed to quantify cough frequency objectively with a cough monitor and investigate its relationship with health status. A secondary aim was to identify clinical predictors of cough frequency. Methods: Fifty-four patients with bronchiectasis were compared with thirty-five healthy controls. Objective 24-h cough, health status (cough-specific: Leicester Cough Questionnaire LCQ and bronchiectasis specific: Bronchiectasis Health Questionnaire BHQ), cough severity and lung function were measured. The clinical predictors of cough frequency in bronchiectasis were determined in a multivariate analysis. Results: Objective cough frequency was significantly raised in patients with bronchiectasis compared to healthy controls [geometric mean (standard deviation)] 184.5 (4.0) vs. 20.6 (3.2) coughs/24-h; mean fold-difference (95% confidence interval) 8.9 (5.2, 15.2); p < 0.001 and they had impaired health status. There was a significant correlation between objective cough frequency and subjective measures; LCQ r = −0.52 and BHQ r = −0.62, both p < 0.001. Sputum production, exacerbations (between past 2 weeks to 12 months) and age were significantly associated with objective cough frequency in multivariate analysis, explaining 52% of the variance (p < 0.001). There was no statistically significant association between cough frequency and lung function. Conclusions: Cough is a common and significant symptom in patients with bronchiectasis. Sputum production, exacerbations and age, but not lung function, were independent predictors of cough frequency. Ambulatory objective cough monitoring provides novel insights and should be further investigated as an outcome measure in bronchiectasis.

KW - Bronchiectasis

KW - Bronchiectasis Health Questionnaire

KW - Cough frequency

KW - Leicester cough monitor

KW - Visual analogue scale

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U2 - 10.1007/s00408-017-0038-x

DO - 10.1007/s00408-017-0038-x

M3 - Article

AN - SCOPUS:85023773419

SN - 0341-2040

VL - 195

SP - 575

EP - 585

JO - Lung

JF - Lung

IS - 5

ER -

The Objective Assessment of Cough Frequency in Bronchiectasis

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Keywords

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