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The p factor: Genetic analyses support a general dimension of psychopathology in childhood and adolescence: Genetic analyses support a general dimension of psychopathology in childhood and adolescence

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The p factor: Genetic analyses support a general dimension of psychopathology in childhood and adolescence : Genetic analyses support a general dimension of psychopathology in childhood and adolescence. / Cheesman, Rosa; Allegrini, Andrea Giuseppe; Rimfeld, Kaili; Selzam, Saskia; Pingault, Jean-Baptiste; Eley, Thalia Catherine; Plomin, Robert Joseph.

In: Journal of Child Psychology and Psychiatry, 09.07.2019.

Research output: Contribution to journalArticle

Harvard

Cheesman, R, Allegrini, AG, Rimfeld, K, Selzam, S, Pingault, J-B, Eley, TC & Plomin, RJ 2019, 'The p factor: Genetic analyses support a general dimension of psychopathology in childhood and adolescence: Genetic analyses support a general dimension of psychopathology in childhood and adolescence', Journal of Child Psychology and Psychiatry.

APA

Cheesman, R., Allegrini, A. G., Rimfeld, K., Selzam, S., Pingault, J-B., Eley, T. C., & Plomin, R. J. (Accepted/In press). The p factor: Genetic analyses support a general dimension of psychopathology in childhood and adolescence: Genetic analyses support a general dimension of psychopathology in childhood and adolescence. Journal of Child Psychology and Psychiatry.

Vancouver

Cheesman R, Allegrini AG, Rimfeld K, Selzam S, Pingault J-B, Eley TC et al. The p factor: Genetic analyses support a general dimension of psychopathology in childhood and adolescence: Genetic analyses support a general dimension of psychopathology in childhood and adolescence. Journal of Child Psychology and Psychiatry. 2019 Jul 9.

Author

Cheesman, Rosa ; Allegrini, Andrea Giuseppe ; Rimfeld, Kaili ; Selzam, Saskia ; Pingault, Jean-Baptiste ; Eley, Thalia Catherine ; Plomin, Robert Joseph. / The p factor: Genetic analyses support a general dimension of psychopathology in childhood and adolescence : Genetic analyses support a general dimension of psychopathology in childhood and adolescence. In: Journal of Child Psychology and Psychiatry. 2019.

Bibtex Download

@article{ae2fa80fe33d4e29a748fe6786f2879b,
title = "The p factor: Genetic analyses support a general dimension of psychopathology in childhood and adolescence: Genetic analyses support a general dimension of psychopathology in childhood and adolescence",
abstract = "Background. Diverse behaviour problems in childhood correlate phenotypically, suggesting a general dimension of psychopathology that has been called the p factor. The shared genetic architecture between childhood psychopathology traits also supports a genetic p. This study systematically investigates the manifestation of this common dimension across self-, parent- and teacher-rated measures in childhood and adolescence.Methods. The sample included 7,026 twin pairs from the Twins Early Development Study (TEDS). First, we employed multivariate twin models to estimate common genetic and environmental influences on p based on diverse measures of behaviour problems rated by children, parents and teachers at ages 7, 9, 12 and 16 (depressive traits, emotional problems, peer problems, autism traits, hyperactivity, antisocial behaviour, conduct problems and psychopathic tendencies). Second, to assess the stability of genetic and environmental influences on p across time, we conducted longitudinal twin modelling of the first phenotypic principal components of childhood psychopathological measures across each of the four ages. Third, we created a genetic p factor in 7,026 unrelated genotyped individuals based on eight polygenic scores for psychiatric disorders to estimate how a general polygenic predisposition to mostly adult psychiatric disorders relates to childhood p. Results. Behaviour problems were consistently correlated phenotypically and genetically across ages and raters. The p factor is substantially heritable (50-60{\%}), and manifests consistently across diverse ages and raters. However, residual variation in the common factor models indicates unique contributions as well. Genetic correlations of p components across childhood and adolescence suggest stability over time (49-78{\%}). A polygenic general psychopathology factor, derived from studies of psychiatric disorders consistently predicted a general phenotypic p factor across development (0.3{\%} - 0.9{\%}). Conclusions. Diverse forms of psychopathology generally load on a common p factor, which is highly heritable. There are substantial genetic influences on the stability of p across childhood. Our analyses indicate genetic overlap between general risk for psychiatric disorders in adulthood and p in childhood, even as young as age 7. The p factor has far-reaching implications for genomic research and, eventually, for diagnosis and treatment of behaviour problems.",
author = "Rosa Cheesman and Allegrini, {Andrea Giuseppe} and Kaili Rimfeld and Saskia Selzam and Jean-Baptiste Pingault and Eley, {Thalia Catherine} and Plomin, {Robert Joseph}",
year = "2019",
month = "7",
day = "9",
language = "English",
journal = "Journal of Child Psychology and Psychiatry",
issn = "0021-9630",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The p factor: Genetic analyses support a general dimension of psychopathology in childhood and adolescence

T2 - Genetic analyses support a general dimension of psychopathology in childhood and adolescence

AU - Cheesman, Rosa

AU - Allegrini, Andrea Giuseppe

AU - Rimfeld, Kaili

AU - Selzam, Saskia

AU - Pingault, Jean-Baptiste

AU - Eley, Thalia Catherine

AU - Plomin, Robert Joseph

PY - 2019/7/9

Y1 - 2019/7/9

N2 - Background. Diverse behaviour problems in childhood correlate phenotypically, suggesting a general dimension of psychopathology that has been called the p factor. The shared genetic architecture between childhood psychopathology traits also supports a genetic p. This study systematically investigates the manifestation of this common dimension across self-, parent- and teacher-rated measures in childhood and adolescence.Methods. The sample included 7,026 twin pairs from the Twins Early Development Study (TEDS). First, we employed multivariate twin models to estimate common genetic and environmental influences on p based on diverse measures of behaviour problems rated by children, parents and teachers at ages 7, 9, 12 and 16 (depressive traits, emotional problems, peer problems, autism traits, hyperactivity, antisocial behaviour, conduct problems and psychopathic tendencies). Second, to assess the stability of genetic and environmental influences on p across time, we conducted longitudinal twin modelling of the first phenotypic principal components of childhood psychopathological measures across each of the four ages. Third, we created a genetic p factor in 7,026 unrelated genotyped individuals based on eight polygenic scores for psychiatric disorders to estimate how a general polygenic predisposition to mostly adult psychiatric disorders relates to childhood p. Results. Behaviour problems were consistently correlated phenotypically and genetically across ages and raters. The p factor is substantially heritable (50-60%), and manifests consistently across diverse ages and raters. However, residual variation in the common factor models indicates unique contributions as well. Genetic correlations of p components across childhood and adolescence suggest stability over time (49-78%). A polygenic general psychopathology factor, derived from studies of psychiatric disorders consistently predicted a general phenotypic p factor across development (0.3% - 0.9%). Conclusions. Diverse forms of psychopathology generally load on a common p factor, which is highly heritable. There are substantial genetic influences on the stability of p across childhood. Our analyses indicate genetic overlap between general risk for psychiatric disorders in adulthood and p in childhood, even as young as age 7. The p factor has far-reaching implications for genomic research and, eventually, for diagnosis and treatment of behaviour problems.

AB - Background. Diverse behaviour problems in childhood correlate phenotypically, suggesting a general dimension of psychopathology that has been called the p factor. The shared genetic architecture between childhood psychopathology traits also supports a genetic p. This study systematically investigates the manifestation of this common dimension across self-, parent- and teacher-rated measures in childhood and adolescence.Methods. The sample included 7,026 twin pairs from the Twins Early Development Study (TEDS). First, we employed multivariate twin models to estimate common genetic and environmental influences on p based on diverse measures of behaviour problems rated by children, parents and teachers at ages 7, 9, 12 and 16 (depressive traits, emotional problems, peer problems, autism traits, hyperactivity, antisocial behaviour, conduct problems and psychopathic tendencies). Second, to assess the stability of genetic and environmental influences on p across time, we conducted longitudinal twin modelling of the first phenotypic principal components of childhood psychopathological measures across each of the four ages. Third, we created a genetic p factor in 7,026 unrelated genotyped individuals based on eight polygenic scores for psychiatric disorders to estimate how a general polygenic predisposition to mostly adult psychiatric disorders relates to childhood p. Results. Behaviour problems were consistently correlated phenotypically and genetically across ages and raters. The p factor is substantially heritable (50-60%), and manifests consistently across diverse ages and raters. However, residual variation in the common factor models indicates unique contributions as well. Genetic correlations of p components across childhood and adolescence suggest stability over time (49-78%). A polygenic general psychopathology factor, derived from studies of psychiatric disorders consistently predicted a general phenotypic p factor across development (0.3% - 0.9%). Conclusions. Diverse forms of psychopathology generally load on a common p factor, which is highly heritable. There are substantial genetic influences on the stability of p across childhood. Our analyses indicate genetic overlap between general risk for psychiatric disorders in adulthood and p in childhood, even as young as age 7. The p factor has far-reaching implications for genomic research and, eventually, for diagnosis and treatment of behaviour problems.

M3 - Article

JO - Journal of Child Psychology and Psychiatry

JF - Journal of Child Psychology and Psychiatry

SN - 0021-9630

ER -

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