The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum

R N Gogoi; F R Schubert; J P Martinez-Barbera; D Acampora; A Simeone; A Lumsden

doi:10.1016/S0925-4773(02)00067-9

The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum

R N Gogoi, F R Schubert, J P Martinez-Barbera, D Acampora, A Simeone, A Lumsden

King's College London

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this acne is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	213 - 217
Number of pages	5
Journal	Mechanisms of Development
Volume	114
Issue number	1-2
DOIs	https://doi.org/10.1016/S0925-4773(02)00067-9
Publication status	Published - 2002

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abstract = "We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this acne is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.",

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AU - Simeone, A

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The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum

Abstract

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