The pathways for intelligible speech: Multivariate and univariate perspectives

S. Evans; J. S. Kyong; S. Rosen; N. Golestani; J. E. Warren; C. McGettigan; J. Mourão-Miranda; R. J.S. Wise; S. K. Scott

doi:10.1093/cercor/bht083

The pathways for intelligible speech: Multivariate and univariate perspectives

S. Evans^*, J. S. Kyong, S. Rosen, N. Golestani, J. E. Warren, C. McGettigan, J. Mourão-Miranda, R. J.S. Wise, S. K. Scott

^*Corresponding author for this work

Neuroimaging

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

An anterior pathway, concerned with extracting meaning from sound, has been identified in nonhuman primates. An analogous pathway has been suggested in humans, but controversy exists concerning the degree of lateralization and the precise location where responses to intelligible speech emerge. We have demonstrated that the left anterior superior temporal sulcus (STS) responds preferentially to intelligible speech (Scott SK, Blank CC, Rosen S, Wise RJS. 2000. Identification of a pathway for intelligible speech in the left temporal lobe. Brain. 123:2400-2406.). A functional magnetic resonance imaging study in Cerebral Cortex used equivalent stimuli and univariate and multivariate analyses to argue for the greater importance of bilateral posterior when compared with the left anterior STS in responding to intelligible speech (Okada K, Rong F, Venezia J, Matchin W, Hsieh IH, Saberi K, Serences JT,Hickok G. 2010. Hierarchical organization of human auditory cortex: evidence from acoustic invariance in the response to intelligible speech. 20: 2486-2495.). Here, we also replicate our original study, demonstrating that the left anterior STS exhibits the strongest univariate response and, in decoding using the bilateral temporal cortex, contains the most informative voxels showing an increased response to intelligible speech. In contrast, in classifications using local "searchlights" and a whole brain analysis, we find greater classification accuracy in posterior rather than anterior temporal regions. Thus, we show that the precise nature of the multivariate analysis used will emphasize different response profiles associated with complex sound to speech processing.

Original language	English
Pages (from-to)	2350-2361
Number of pages	12
Journal	Cerebral Cortex
Volume	24
Issue number	9
DOIs	https://doi.org/10.1093/cercor/bht083
Publication status	Published - Sept 2014

Keywords

fMRI
Intelligibility
Multivariate pattern analysis
Speech perception
Superior temporal sulcus

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10.1093/cercor/bht083

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@article{3e375a47c85f4f478855297ce72c5212,

title = "The pathways for intelligible speech: Multivariate and univariate perspectives",

abstract = "An anterior pathway, concerned with extracting meaning from sound, has been identified in nonhuman primates. An analogous pathway has been suggested in humans, but controversy exists concerning the degree of lateralization and the precise location where responses to intelligible speech emerge. We have demonstrated that the left anterior superior temporal sulcus (STS) responds preferentially to intelligible speech (Scott SK, Blank CC, Rosen S, Wise RJS. 2000. Identification of a pathway for intelligible speech in the left temporal lobe. Brain. 123:2400-2406.). A functional magnetic resonance imaging study in Cerebral Cortex used equivalent stimuli and univariate and multivariate analyses to argue for the greater importance of bilateral posterior when compared with the left anterior STS in responding to intelligible speech (Okada K, Rong F, Venezia J, Matchin W, Hsieh IH, Saberi K, Serences JT,Hickok G. 2010. Hierarchical organization of human auditory cortex: evidence from acoustic invariance in the response to intelligible speech. 20: 2486-2495.). Here, we also replicate our original study, demonstrating that the left anterior STS exhibits the strongest univariate response and, in decoding using the bilateral temporal cortex, contains the most informative voxels showing an increased response to intelligible speech. In contrast, in classifications using local {"}searchlights{"} and a whole brain analysis, we find greater classification accuracy in posterior rather than anterior temporal regions. Thus, we show that the precise nature of the multivariate analysis used will emphasize different response profiles associated with complex sound to speech processing.",

keywords = "fMRI, Intelligibility, Multivariate pattern analysis, Speech perception, Superior temporal sulcus",

author = "S. Evans and Kyong, {J. S.} and S. Rosen and N. Golestani and Warren, {J. E.} and C. McGettigan and J. Mour{\~a}o-Miranda and Wise, {R. J.S.} and Scott, {S. K.}",

note = "Funding Information: This work was supported by the Wellcome Trust (WT074414MA to S.K.S.). J.M.M. is funded by a Wellcome Trust Career Development Fellowship. S.E. was supported by an ESRC studentship. Funding to pay the Open Access publication charges for this article was provided by the Wellcome Trust.",

year = "2014",

month = sep,

doi = "10.1093/cercor/bht083",

language = "English",

volume = "24",

pages = "2350--2361",

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T2 - Multivariate and univariate perspectives

AU - Evans, S.

AU - Kyong, J. S.

AU - Rosen, S.

AU - Golestani, N.

AU - Warren, J. E.

AU - McGettigan, C.

AU - Mourão-Miranda, J.

AU - Wise, R. J.S.

AU - Scott, S. K.

N1 - Funding Information: This work was supported by the Wellcome Trust (WT074414MA to S.K.S.). J.M.M. is funded by a Wellcome Trust Career Development Fellowship. S.E. was supported by an ESRC studentship. Funding to pay the Open Access publication charges for this article was provided by the Wellcome Trust.

PY - 2014/9

Y1 - 2014/9

N2 - An anterior pathway, concerned with extracting meaning from sound, has been identified in nonhuman primates. An analogous pathway has been suggested in humans, but controversy exists concerning the degree of lateralization and the precise location where responses to intelligible speech emerge. We have demonstrated that the left anterior superior temporal sulcus (STS) responds preferentially to intelligible speech (Scott SK, Blank CC, Rosen S, Wise RJS. 2000. Identification of a pathway for intelligible speech in the left temporal lobe. Brain. 123:2400-2406.). A functional magnetic resonance imaging study in Cerebral Cortex used equivalent stimuli and univariate and multivariate analyses to argue for the greater importance of bilateral posterior when compared with the left anterior STS in responding to intelligible speech (Okada K, Rong F, Venezia J, Matchin W, Hsieh IH, Saberi K, Serences JT,Hickok G. 2010. Hierarchical organization of human auditory cortex: evidence from acoustic invariance in the response to intelligible speech. 20: 2486-2495.). Here, we also replicate our original study, demonstrating that the left anterior STS exhibits the strongest univariate response and, in decoding using the bilateral temporal cortex, contains the most informative voxels showing an increased response to intelligible speech. In contrast, in classifications using local "searchlights" and a whole brain analysis, we find greater classification accuracy in posterior rather than anterior temporal regions. Thus, we show that the precise nature of the multivariate analysis used will emphasize different response profiles associated with complex sound to speech processing.

AB - An anterior pathway, concerned with extracting meaning from sound, has been identified in nonhuman primates. An analogous pathway has been suggested in humans, but controversy exists concerning the degree of lateralization and the precise location where responses to intelligible speech emerge. We have demonstrated that the left anterior superior temporal sulcus (STS) responds preferentially to intelligible speech (Scott SK, Blank CC, Rosen S, Wise RJS. 2000. Identification of a pathway for intelligible speech in the left temporal lobe. Brain. 123:2400-2406.). A functional magnetic resonance imaging study in Cerebral Cortex used equivalent stimuli and univariate and multivariate analyses to argue for the greater importance of bilateral posterior when compared with the left anterior STS in responding to intelligible speech (Okada K, Rong F, Venezia J, Matchin W, Hsieh IH, Saberi K, Serences JT,Hickok G. 2010. Hierarchical organization of human auditory cortex: evidence from acoustic invariance in the response to intelligible speech. 20: 2486-2495.). Here, we also replicate our original study, demonstrating that the left anterior STS exhibits the strongest univariate response and, in decoding using the bilateral temporal cortex, contains the most informative voxels showing an increased response to intelligible speech. In contrast, in classifications using local "searchlights" and a whole brain analysis, we find greater classification accuracy in posterior rather than anterior temporal regions. Thus, we show that the precise nature of the multivariate analysis used will emphasize different response profiles associated with complex sound to speech processing.

KW - fMRI

KW - Intelligibility

KW - Multivariate pattern analysis

KW - Speech perception

KW - Superior temporal sulcus

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DO - 10.1093/cercor/bht083

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AN - SCOPUS:84906976733

SN - 1047-3211

VL - 24

SP - 2350

EP - 2361

JO - Cerebral Cortex

JF - Cerebral Cortex

IS - 9

ER -

The pathways for intelligible speech: Multivariate and univariate perspectives

Abstract

Keywords

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