The perinucleolar compartment: structure, function, and utility in anti-cancer drug development

TY - JOUR

T1 - The perinucleolar compartment

T2 - structure, function, and utility in anti-cancer drug development

AU - Makeyev, Eugene V.

AU - Huang, Sui

N1 - Funding Information: Work in our laboratories has been supported by NIH [S.H.: U01CA260699, and R01 CA269967] and Biotechnology and Biological Sciences Research Council [E.V.M.; BB/M001199/1, BB/R001049/1, and BB/V006258/1]. Publisher Copyright: © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

PY - 2024/12

Y1 - 2024/12

N2 - The perinucleolar compartment (PNC) was initially identified as a nuclear structure enriched for the polypyrimidine tract-binding protein. Since then, the PNC has been implicated in carcinogenesis. The prevalence of this compartment is positively correlated with disease progression in various types of cancer, and its expression in primary tumors is linked to worse patient outcomes. Using the PNC as a surrogate marker for anti-cancer drug efficacy has led to the development of a clinical candidate for anti-metastasis therapies. The PNC is a multicomponent nuclear body situated at the periphery of the nucleolus. Thus far, several non-coding RNAs and RNA-binding proteins have been identified as the PNC components. Here, we summarize the current understanding of the structure and function of the PNC, as well as its recurrent links to cancer progression and metastasis.

AB - The perinucleolar compartment (PNC) was initially identified as a nuclear structure enriched for the polypyrimidine tract-binding protein. Since then, the PNC has been implicated in carcinogenesis. The prevalence of this compartment is positively correlated with disease progression in various types of cancer, and its expression in primary tumors is linked to worse patient outcomes. Using the PNC as a surrogate marker for anti-cancer drug efficacy has led to the development of a clinical candidate for anti-metastasis therapies. The PNC is a multicomponent nuclear body situated at the periphery of the nucleolus. Thus far, several non-coding RNAs and RNA-binding proteins have been identified as the PNC components. Here, we summarize the current understanding of the structure and function of the PNC, as well as its recurrent links to cancer progression and metastasis.

KW - Anti-cancer drug development

KW - non-coding RNA

KW - nucleolus

KW - PNC

KW - RNA binding proteins

UR - http://www.scopus.com/inward/record.url?scp=85183640568&partnerID=8YFLogxK

U2 - 10.1080/19491034.2024.2306777

DO - 10.1080/19491034.2024.2306777

M3 - Article

AN - SCOPUS:85183640568

SN - 1949-1034

VL - 15

JO - Nucleus

JF - Nucleus

IS - 1

M1 - 2306777

ER -