The plasticity of cytoskeletal dynamics underlying neoplastic cell migration

V Sanz-Moreno; CJ Marshall

doi:10.1016/j.ceb.2010.08.020

The plasticity of cytoskeletal dynamics underlying neoplastic cell migration

V Sanz-Moreno, CJ Marshall

Research output: Contribution to journal › Article › peer-review

198 Citations (Scopus)

Abstract

Due to the use of intra-vital imaging techniques and assays for cell migration into 3D matrices there has recently been much interest in different modes of tumour cell migration. Individually moving tumour cells can move either in an elongated-protrusive manner or in rounded, so-called ‘amoeboid’ modes. This review summarises ongoing efforts to delineate the cell signalling pathways that underlie these different forms of movement.

Original language	English
Pages (from-to)	690 - 696
Number of pages	7
Journal	Current Opinion in Cell Biology
Volume	22
Issue number	5
DOIs	https://doi.org/10.1016/j.ceb.2010.08.020
Publication status	Published - Oct 2010

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title = "The plasticity of cytoskeletal dynamics underlying neoplastic cell migration",

abstract = "Due to the use of intra-vital imaging techniques and assays for cell migration into 3D matrices there has recently been much interest in different modes of tumour cell migration. Individually moving tumour cells can move either in an elongated-protrusive manner or in rounded, so-called {\textquoteleft}amoeboid{\textquoteright} modes. This review summarises ongoing efforts to delineate the cell signalling pathways that underlie these different forms of movement.",

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AB - Due to the use of intra-vital imaging techniques and assays for cell migration into 3D matrices there has recently been much interest in different modes of tumour cell migration. Individually moving tumour cells can move either in an elongated-protrusive manner or in rounded, so-called ‘amoeboid’ modes. This review summarises ongoing efforts to delineate the cell signalling pathways that underlie these different forms of movement.

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DO - 10.1016/j.ceb.2010.08.020

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JO - Current Opinion in Cell Biology

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The plasticity of cytoskeletal dynamics underlying neoplastic cell migration

Abstract

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