The Potential Effect of Blueberry on Cognitive Health and Mood State based on Human Intervention Studies: Systematic Review and Mini Meta-Analysis

Neda Soveid, Bahareh Barkhidarian, Sajjad Moradi, Fatemeh Gholami, Niloufar Rasaei, Hubertus Himmerich, Khadijeh Mirzaei*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background: Blueberries are known for their high content of several bioactive compounds, specifically anthocyanin, which are the most beneficial of the flavonoid family in terms of neuropro-tection. Several human interventional studies have been conducted to assess the effects of blueberry intake on cognitive performance; however, the results of clinical trials are inconclusive. Therefore, this systematic review and meta-analysis evaluated the effect of blueberry supplementation on some aspects of cognitive performance and mood parameters using data from clinical trials based on existing evidence. Methods: Relevant studies, published in April 2021, were searched through PubMed/Medline, Scopus, Embase, and Google Scholar. The random effect size was used to estimate the pooled effect size. Heterogeneity between studies was evaluated by the Cochrane Q test and I-squared (I2). To detect the potential source of heterogeneity, a subgroup analysis was conducted. Results: Fourteenrandomized trials were included in the quantitative analysis, and six were pooled for statistical analysis. Blueberry intervention resulted in no significant change in mood state score (WMD = 0.03; 95% CI:-0.80 to 0.87, P = 0.16). Moreover, no significant effect of blueberry intake was shown in attention task reaction time (WMD =-1.50 ms; 95% CI:-24.75 to-21.75, P = 0.9), per-centages of attention task accuracy (WMD = 0.85; 95% CI:-2.57 to 0.86, P = 0.3), one-back test accuracy (WMD = 0.03; 95% CI:-0.04 to 0.09, P = 0.4). Significant effect was indicated (WMD = 0.08; 95% CI: 0.02 to 0.13, P = 0.005) in two-back test accuracy. Conclusion: We found a significant effect of blueberry consumption on two-back test accuracy as a cognitive outcome. More high-quality clinical trials according to the challenges mentioned seem to in-dicate the use of blueberry as a supplement for cognitive and mood health efficiently.

Original languageEnglish
Pages (from-to)1090-1101
Number of pages12
JournalCNS and Neurological Disorders - Drug Targets
Issue number7
Publication statusPublished - 2023


  • anthocyanin
  • Blueberry
  • cognition
  • human
  • intervention
  • mood


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