The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties

Khondaker M. Rahman; Mohammad D. Hossain; Mohammad H. Sohrab; Alex F. Drake; Tam T. Bui; Jarmila Husby; Mekala Gunaratnam; Stephen Neidle; Choudhury M. Hasan; David E. Thurston

doi:10.1039/c2cc31277h

The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties

Khondaker M. Rahman, Mohammad D. Hossain, Mohammad H. Sohrab, Alex F. Drake, Tam T. Bui, Jarmila Husby, Mekala Gunaratnam, Stephen Neidle, Choudhury M. Hasan, David E. Thurston

Institute of Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Cristatin A (1a/b), a prenylated dioxopiperazine alkaloid, has been shown to bind selectively to telomeric quadruplex DNA using a FRET-based DNA melting assay. Crucially, the molecule is more drug-like than most previously identified quadruplex-binding agents, and provides a unique chemical scaffold for future chemical biology and drug discovery studies.

Original language	English
Pages (from-to)	8760-8762
Number of pages	3
Journal	CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY
Volume	48
Issue number	70
Early online date	6 Jun 2012
DOIs	https://doi.org/10.1039/c2cc31277h
Publication status	Published - 11 Sept 2012

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Rahman, K. M., Hossain, M. D., Sohrab, M. H., Drake, A. F., Bui, T. T., Husby, J., Gunaratnam, M., Neidle, S., Hasan, C. M., & Thurston, D. E. (2012). The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties. CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY, 48(70), 8760-8762. https://doi.org/10.1039/c2cc31277h

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abstract = "Cristatin A (1a/b), a prenylated dioxopiperazine alkaloid, has been shown to bind selectively to telomeric quadruplex DNA using a FRET-based DNA melting assay. Crucially, the molecule is more drug-like than most previously identified quadruplex-binding agents, and provides a unique chemical scaffold for future chemical biology and drug discovery studies.",

author = "Rahman, {Khondaker M.} and Hossain, {Mohammad D.} and Sohrab, {Mohammad H.} and Drake, {Alex F.} and Bui, {Tam T.} and Jarmila Husby and Mekala Gunaratnam and Stephen Neidle and Hasan, {Choudhury M.} and Thurston, {David E.}",

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AU - Rahman, Khondaker M.

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AU - Sohrab, Mohammad H.

AU - Drake, Alex F.

AU - Bui, Tam T.

AU - Husby, Jarmila

AU - Gunaratnam, Mekala

AU - Neidle, Stephen

AU - Hasan, Choudhury M.

AU - Thurston, David E.

PY - 2012/9/11

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AB - Cristatin A (1a/b), a prenylated dioxopiperazine alkaloid, has been shown to bind selectively to telomeric quadruplex DNA using a FRET-based DNA melting assay. Crucially, the molecule is more drug-like than most previously identified quadruplex-binding agents, and provides a unique chemical scaffold for future chemical biology and drug discovery studies.

U2 - 10.1039/c2cc31277h

DO - 10.1039/c2cc31277h

M3 - Article

SN - 1359-7345

VL - 48

SP - 8760

EP - 8762

JO - CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY

JF - CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY

IS - 70

ER -

The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties

Abstract

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