The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties

TY - JOUR

T1 - The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties

AU - Rahman, Khondaker M.

AU - Hossain, Mohammad D.

AU - Sohrab, Mohammad H.

AU - Drake, Alex F.

AU - Bui, Tam T.

AU - Husby, Jarmila

AU - Gunaratnam, Mekala

AU - Neidle, Stephen

AU - Hasan, Choudhury M.

AU - Thurston, David E.

PY - 2012/9/11

Y1 - 2012/9/11

N2 - Cristatin A (1a/b), a prenylated dioxopiperazine alkaloid, has been shown to bind selectively to telomeric quadruplex DNA using a FRET-based DNA melting assay. Crucially, the molecule is more drug-like than most previously identified quadruplex-binding agents, and provides a unique chemical scaffold for future chemical biology and drug discovery studies.

AB - Cristatin A (1a/b), a prenylated dioxopiperazine alkaloid, has been shown to bind selectively to telomeric quadruplex DNA using a FRET-based DNA melting assay. Crucially, the molecule is more drug-like than most previously identified quadruplex-binding agents, and provides a unique chemical scaffold for future chemical biology and drug discovery studies.

U2 - 10.1039/c2cc31277h

DO - 10.1039/c2cc31277h

M3 - Article

SN - 1359-7345

VL - 48

SP - 8760

EP - 8762

JO - CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY

JF - CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY

IS - 70

ER -