The prevalence of diabetes mellitus and abnormal glucose metabolism in the inpatient psychiatric setting: A systematic review and meta-analysis

TY - JOUR

T1 - The prevalence of diabetes mellitus and abnormal glucose metabolism in the inpatient psychiatric setting

T2 - A systematic review and meta-analysis

AU - Roberts, Emmert

AU - Jones, Leah

AU - Blackman, Alexandra

AU - Dewhurst, Thomas

AU - Matcham, Faith

AU - Kan, Carol

AU - Mustafa, Omar

AU - Thomas, Toral

AU - Siddiqi, Najma

AU - Ismail, Khalida

AU - Price, Hermione

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Objective To systematically determine the prevalence of diabetes mellitus (DM), impaired fasting glucose (IFG), and impaired glucose tolerance (IGT) in psychiatric inpatients and explore the impact of patient and study variables on prevalence estimates. Method We searched EMBASE, PsychINFO, Medline and CENTRAL from database inception until 1st December 2015. We included studies of any design reporting prevalence of abnormal glucose metabolism in any adult psychiatric inpatients. We conducted a random effects meta-analysis to generate pooled prevalence estimates. Chi-square tests compared differences within categorical variables (inpatient setting, continent of study and patient diagnostic category) and Spearman's correlation analyses assessed the impact of linear variables (age, year of data collection and study quality). Study quality was assessed using an adapted Newcastle-Ottawa Scale. Results 36 study reports representing 42 unique cohorts were included. Across all studies prevalence of unspecified type DM was 10% (95%CI: 9–12), of T1DM was 1% (0–1), of T2DM was 9% (6–13), of IFG 18% (8–28), and of IGT was 22% (16–28). These estimates were not affected by study quality. Conclusions All estimates are higher compared to the general population. Mental health professionals should be aware of this elevated prevalence to improve screening and management of abnormal glucose metabolism.

AB - Objective To systematically determine the prevalence of diabetes mellitus (DM), impaired fasting glucose (IFG), and impaired glucose tolerance (IGT) in psychiatric inpatients and explore the impact of patient and study variables on prevalence estimates. Method We searched EMBASE, PsychINFO, Medline and CENTRAL from database inception until 1st December 2015. We included studies of any design reporting prevalence of abnormal glucose metabolism in any adult psychiatric inpatients. We conducted a random effects meta-analysis to generate pooled prevalence estimates. Chi-square tests compared differences within categorical variables (inpatient setting, continent of study and patient diagnostic category) and Spearman's correlation analyses assessed the impact of linear variables (age, year of data collection and study quality). Study quality was assessed using an adapted Newcastle-Ottawa Scale. Results 36 study reports representing 42 unique cohorts were included. Across all studies prevalence of unspecified type DM was 10% (95%CI: 9–12), of T1DM was 1% (0–1), of T2DM was 9% (6–13), of IFG 18% (8–28), and of IGT was 22% (16–28). These estimates were not affected by study quality. Conclusions All estimates are higher compared to the general population. Mental health professionals should be aware of this elevated prevalence to improve screening and management of abnormal glucose metabolism.

KW - Diabetes mellitus

KW - Inpatient psychiatry

KW - Serious mental illness

UR - http://www.scopus.com/inward/record.url?scp=85010032174&partnerID=8YFLogxK

U2 - 10.1016/j.genhosppsych.2017.01.003

DO - 10.1016/j.genhosppsych.2017.01.003

M3 - Article

AN - SCOPUS:85010032174

SN - 0163-8343

VL - 45

SP - 76

EP - 84

JO - GENERAL HOSPITAL PSYCHIATRY

JF - GENERAL HOSPITAL PSYCHIATRY

M1 - 76

ER -