The primary cilia: Orchestrating cranial neural crest cell development

Hiroyuki Yamaguchi; Matthew D Meyer; William Barrell; Maryam Faisal; Rebecca Berdeaux; Karen Liu; Yoshihiro Komatsu

The primary cilia: Orchestrating cranial neural crest cell development

Hiroyuki Yamaguchi, Matthew D Meyer, William Barrell, Maryam Faisal, Rebecca Berdeaux, Karen Liu, Yoshihiro Komatsu^*

^*Corresponding author for this work

Centre for Craniofacial & Regenerative Biology

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Primary cilia (hereafter "cilia") are microtubule-based antenna-like organelles projecting from the surface of vertebrate cells. Cilia can serve as cellular antennae controlling cell growth and differentiation. Absent or dysfunctional cilia frequently lead to craniofacial anomalies known as craniofacial ciliopathies. However, the detailed pathological mechanisms of craniofacial ciliopathies remain unclear. This perspective discusses our current understanding of the role of cilia in cranial neural crest cells. We also describe potential mechanisms of ciliogenesis in cranial neural crest cells, which may contribute to unraveling the complex pathogenesis of craniofacial ciliopathies.

Original language	English
Journal	Differentiation
Publication status	Published - 30 Oct 2024

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http://10.1016/j.diff.2024.100818Licence: CC BY

Cite this

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title = "The primary cilia: Orchestrating cranial neural crest cell development",

abstract = "Primary cilia (hereafter {"}cilia{"}) are microtubule-based antenna-like organelles projecting from the surface of vertebrate cells. Cilia can serve as cellular antennae controlling cell growth and differentiation. Absent or dysfunctional cilia frequently lead to craniofacial anomalies known as craniofacial ciliopathies. However, the detailed pathological mechanisms of craniofacial ciliopathies remain unclear. This perspective discusses our current understanding of the role of cilia in cranial neural crest cells. We also describe potential mechanisms of ciliogenesis in cranial neural crest cells, which may contribute to unraveling the complex pathogenesis of craniofacial ciliopathies.",

author = "Hiroyuki Yamaguchi and Meyer, {Matthew D} and William Barrell and Maryam Faisal and Rebecca Berdeaux and Karen Liu and Yoshihiro Komatsu",

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language = "English",

journal = "Differentiation",

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TY - JOUR

T1 - The primary cilia: Orchestrating cranial neural crest cell development

AU - Yamaguchi, Hiroyuki

AU - Meyer, Matthew D

AU - Barrell, William

AU - Faisal, Maryam

AU - Berdeaux, Rebecca

AU - Liu, Karen

AU - Komatsu, Yoshihiro

PY - 2024/10/30

Y1 - 2024/10/30

N2 - Primary cilia (hereafter "cilia") are microtubule-based antenna-like organelles projecting from the surface of vertebrate cells. Cilia can serve as cellular antennae controlling cell growth and differentiation. Absent or dysfunctional cilia frequently lead to craniofacial anomalies known as craniofacial ciliopathies. However, the detailed pathological mechanisms of craniofacial ciliopathies remain unclear. This perspective discusses our current understanding of the role of cilia in cranial neural crest cells. We also describe potential mechanisms of ciliogenesis in cranial neural crest cells, which may contribute to unraveling the complex pathogenesis of craniofacial ciliopathies.

AB - Primary cilia (hereafter "cilia") are microtubule-based antenna-like organelles projecting from the surface of vertebrate cells. Cilia can serve as cellular antennae controlling cell growth and differentiation. Absent or dysfunctional cilia frequently lead to craniofacial anomalies known as craniofacial ciliopathies. However, the detailed pathological mechanisms of craniofacial ciliopathies remain unclear. This perspective discusses our current understanding of the role of cilia in cranial neural crest cells. We also describe potential mechanisms of ciliogenesis in cranial neural crest cells, which may contribute to unraveling the complex pathogenesis of craniofacial ciliopathies.

M3 - Review article

SN - 0301-4681

JO - Differentiation

JF - Differentiation

ER -

The primary cilia: Orchestrating cranial neural crest cell development

Abstract

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