THE PROTON NMR-SPECTRUM IN ACUTE EAE - THE SIGNIFICANCE OF THE CHANGE IN THE CHO-CR RATIO

R E  BRENNER; P M G  MUNRO; S C R  WILLIAMS; J D  BELL; G J  BARKER; C P  HAWKINS; D N  LANDON; W I  MCDONALD

doi:10.1002/mrm.1910290605

THE PROTON NMR-SPECTRUM IN ACUTE EAE - THE SIGNIFICANCE OF THE CHANGE IN THE CHO-CR RATIO

R E BRENNER, P M G MUNRO, S C R WILLIAMS, J D BELL, G J BARKER, C P HAWKINS, D N LANDON, W I MCDONALD

Neuroimaging

UCL University College London

Research output: Contribution to journal › Article › peer-review

178 Citations (Scopus)

Abstract

We have studied by nuclear magnetic resonance spectroscopy the evolution of the proton spectral changes in acute experimental allergic encephalomyelitis. We found an in vivo elevation in the ratio between the peaks assigned to ''choline containing compounds'' (Cho) and creatine plus phosphocreatine (Cr). This was associated with an increase in choline, betaine, and phosphorylcholine (PC) as well as a reduction in N-acetylaspartate (NAA), aspartate, N-acetylaspartatylglutamate and inositol in vitro. Histological examination revealed inflammation with no evidence of demyelination or neuronal loss. We conclude that the increase in the ratio of Cho:Cr was due to an increase in the concentrations of PC, betaine, and choline in association with inflammation, and not as others have suggested, with demyelination. The reported reduction in NAA may be due to dysfunction of neurones rather than their loss.

Original language	English
Pages (from-to)	737-745
Number of pages	9
Journal	Magnetic Resonance in Medicine
Volume	29
Issue number	6
DOIs	https://doi.org/10.1002/mrm.1910290605
Publication status	Published - Jun 1993

Access to Document

10.1002/mrm.1910290605

Cite this

@article{ca4ced60a71b4960bab0e9d67b6d5924,

title = "THE PROTON NMR-SPECTRUM IN ACUTE EAE - THE SIGNIFICANCE OF THE CHANGE IN THE CHO-CR RATIO",

abstract = "We have studied by nuclear magnetic resonance spectroscopy the evolution of the proton spectral changes in acute experimental allergic encephalomyelitis. We found an in vivo elevation in the ratio between the peaks assigned to ''choline containing compounds'' (Cho) and creatine plus phosphocreatine (Cr). This was associated with an increase in choline, betaine, and phosphorylcholine (PC) as well as a reduction in N-acetylaspartate (NAA), aspartate, N-acetylaspartatylglutamate and inositol in vitro. Histological examination revealed inflammation with no evidence of demyelination or neuronal loss. We conclude that the increase in the ratio of Cho:Cr was due to an increase in the concentrations of PC, betaine, and choline in association with inflammation, and not as others have suggested, with demyelination. The reported reduction in NAA may be due to dysfunction of neurones rather than their loss.",

author = "BRENNER, {R E} and MUNRO, {P M G} and WILLIAMS, {S C R} and BELL, {J D} and BARKER, {G J} and HAWKINS, {C P} and LANDON, {D N} and MCDONALD, {W I}",

year = "1993",

month = jun,

doi = "10.1002/mrm.1910290605",

language = "English",

volume = "29",

pages = "737--745",

journal = "Magnetic Resonance in Medicine",

issn = "0740-3194",

publisher = "Wiley",

number = "6",

}

TY - JOUR

T1 - THE PROTON NMR-SPECTRUM IN ACUTE EAE - THE SIGNIFICANCE OF THE CHANGE IN THE CHO-CR RATIO

AU - BRENNER, R E

AU - MUNRO, P M G

AU - WILLIAMS, S C R

AU - BELL, J D

AU - BARKER, G J

AU - HAWKINS, C P

AU - LANDON, D N

AU - MCDONALD, W I

PY - 1993/6

Y1 - 1993/6

N2 - We have studied by nuclear magnetic resonance spectroscopy the evolution of the proton spectral changes in acute experimental allergic encephalomyelitis. We found an in vivo elevation in the ratio between the peaks assigned to ''choline containing compounds'' (Cho) and creatine plus phosphocreatine (Cr). This was associated with an increase in choline, betaine, and phosphorylcholine (PC) as well as a reduction in N-acetylaspartate (NAA), aspartate, N-acetylaspartatylglutamate and inositol in vitro. Histological examination revealed inflammation with no evidence of demyelination or neuronal loss. We conclude that the increase in the ratio of Cho:Cr was due to an increase in the concentrations of PC, betaine, and choline in association with inflammation, and not as others have suggested, with demyelination. The reported reduction in NAA may be due to dysfunction of neurones rather than their loss.

AB - We have studied by nuclear magnetic resonance spectroscopy the evolution of the proton spectral changes in acute experimental allergic encephalomyelitis. We found an in vivo elevation in the ratio between the peaks assigned to ''choline containing compounds'' (Cho) and creatine plus phosphocreatine (Cr). This was associated with an increase in choline, betaine, and phosphorylcholine (PC) as well as a reduction in N-acetylaspartate (NAA), aspartate, N-acetylaspartatylglutamate and inositol in vitro. Histological examination revealed inflammation with no evidence of demyelination or neuronal loss. We conclude that the increase in the ratio of Cho:Cr was due to an increase in the concentrations of PC, betaine, and choline in association with inflammation, and not as others have suggested, with demyelination. The reported reduction in NAA may be due to dysfunction of neurones rather than their loss.

U2 - 10.1002/mrm.1910290605

DO - 10.1002/mrm.1910290605

M3 - Article

SN - 0740-3194

VL - 29

SP - 737

EP - 745

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 6

ER -

THE PROTON NMR-SPECTRUM IN ACUTE EAE - THE SIGNIFICANCE OF THE CHANGE IN THE CHO-CR RATIO

Abstract

Access to Document

Fingerprint

Cite this