Abstract
Retinal ganglion cells are vital for vision, some have intrinsic light sensing properties and in retinal networks display complex computational abilities. Furthermore they are implicated in a very common form of blindness, glaucoma as well some the symptoms of AIDS. Retinal ganglion cells, unlike many neurones of the central nervous system, have a clearly defined physiological role and can be identified in primary cultures with ease. Here we detail the cell culture and electrophysiological methods required to obtain recordings on the voltage-gated and ligand-gated ion currents and channels expressed by these neurones. Information is given on the range of non-ionotropic receptors that are thought to be present on these cells and what role they may have as model systems in the pharmacological and pharmaceutical research environment.
| Original language | English |
|---|---|
| Pages (from-to) | 209 - 220 |
| Number of pages | 12 |
| Journal | Journal of Pharmacological and Toxicological Methods |
| Volume | 51 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 2005 |
