King's College London

Research portal

The regulation of mitochondrial dynamics in neurite outgrowth by retinoic acid receptor β signaling

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)7225-7235
Number of pages11
JournalFASEB Journal
Issue number6
Early online date11 Mar 2019
Accepted/In press18 Feb 2019
E-pub ahead of print11 Mar 2019
Published1 Jun 2019

Bibliographical note

PMID: 30857414


King's Authors


Neuronal regeneration is a highly energy-demanding process that greatly relies on axonal mitochondrial transport to meet the enhanced metabolic requirements. Mature neurons typically fail to regenerate after injury, partly because of mitochondrial motility and energy deficits in injured axons. Retinoic acid receptor (RAR)-β signaling is involved in axonal and neurite regeneration. Here we investigate the effect of RAR-β signaling on mitochondria trafficking during neurite outgrowth and find that it enhances their proliferation, speed, and movement toward the growing end of the neuron via hypoxia-inducible factor 1α signaling. We also show that RAR-β signaling promotes the binding of the mitochondria to the anchoring protein, glucose-related protein 75, at the growing tip of neurite, thus allowing them to provide energy and metabolic roles required for neurite outgrowth.—Trigo, D., Goncalves, M. B., Corcoran, J. P. T. The regulation of mitochondria dynamics in neurite outgrowth by retinoic acid receptor β signaling.

Download statistics

No data available

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454