The role of apoptosis in the pathogenesis of the myelodysplastic syndromes

J E Parker, G J Mufti

    Research output: Contribution to journalLiterature reviewpeer-review

    42 Citations (Scopus)


    The paradoxical occurrence of peripheral cytopenias despite a normo/hypercellular marrow in myelodysplastic syndromes (MDS) has been attributed to excessive intramedullary hematopoietic cell apoptosis. It has also been postulated that abrogation of programmed cell death (PCD) may underlie MDS transformation to acute myeloid leukemia (AML). Despite overwhelming evidence for a role of aberrant apoptosis in myelodysplasia, the molecular mechanisms responsible for such changes have not been elucidated. This paper summarizes current evidence implicating a role for altered PCD in MDS and outlines potential cellular mechanisms whereby hematopoietic progenitor cell apoptosis may be dysregulated. Int J Hematol. 2001:73:416-428. (C) 2001 The Japanese Society of Hematology.
    Original languageEnglish
    Pages (from-to)416 - 428
    Number of pages13
    JournalInternational Journal of Hematology
    Issue number4
    Publication statusPublished - 2001


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