The role of autophagic degradation in the heart

Kazuhiko Nishida; Manabu Taneike; Kinya Otsu

doi:10.1016/j.yjmcc.2014.09.029

The role of autophagic degradation in the heart

Kazuhiko Nishida, Manabu Taneike, Kinya Otsu^*

^*Corresponding author for this work

King's College London

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Autophagy has evolved as a conserved process for bulk degradation and recycling of cytoplasmic components, such as long-lived proteins and organelles. Macroautophagy is the most prevalent form and thus referred to as autophagy. Autophagy is initially considered to be a non-selective process as an adaptive response to nutrient starvation. However, damaged mitochondria are selectively removed by autophagy, called mitophagy. Autophagy plays essential roles in starvation, cardiac remodeling, reverse remodeling, aging and inflammation to maintain cellular homeostasis in the heart. This review discusses some recent advances in understanding the basic molecular mechanisms underlying autophagosome and autolysosome formation and mitophagy and the roles of autophagy in cardiomyopathy. This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease".

Original language	English
Pages (from-to)	73-79
Number of pages	7
Journal	Journal of Molecular and Cellular Cardiology
Volume	78
DOIs	https://doi.org/10.1016/j.yjmcc.2014.09.029
Publication status	Published - 1 Jan 2015

Keywords

Autophagy
Cardioprotection
Inflammation
Mitochondria
Mitophagy
Reverse remodeling

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.yjmcc.2014.09.029

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title = "The role of autophagic degradation in the heart",

abstract = "Autophagy has evolved as a conserved process for bulk degradation and recycling of cytoplasmic components, such as long-lived proteins and organelles. Macroautophagy is the most prevalent form and thus referred to as autophagy. Autophagy is initially considered to be a non-selective process as an adaptive response to nutrient starvation. However, damaged mitochondria are selectively removed by autophagy, called mitophagy. Autophagy plays essential roles in starvation, cardiac remodeling, reverse remodeling, aging and inflammation to maintain cellular homeostasis in the heart. This review discusses some recent advances in understanding the basic molecular mechanisms underlying autophagosome and autolysosome formation and mitophagy and the roles of autophagy in cardiomyopathy. This article is part of a Special Issue entitled {"}Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease{"}.",

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AU - Taneike, Manabu

AU - Otsu, Kinya

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N2 - Autophagy has evolved as a conserved process for bulk degradation and recycling of cytoplasmic components, such as long-lived proteins and organelles. Macroautophagy is the most prevalent form and thus referred to as autophagy. Autophagy is initially considered to be a non-selective process as an adaptive response to nutrient starvation. However, damaged mitochondria are selectively removed by autophagy, called mitophagy. Autophagy plays essential roles in starvation, cardiac remodeling, reverse remodeling, aging and inflammation to maintain cellular homeostasis in the heart. This review discusses some recent advances in understanding the basic molecular mechanisms underlying autophagosome and autolysosome formation and mitophagy and the roles of autophagy in cardiomyopathy. This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease".

AB - Autophagy has evolved as a conserved process for bulk degradation and recycling of cytoplasmic components, such as long-lived proteins and organelles. Macroautophagy is the most prevalent form and thus referred to as autophagy. Autophagy is initially considered to be a non-selective process as an adaptive response to nutrient starvation. However, damaged mitochondria are selectively removed by autophagy, called mitophagy. Autophagy plays essential roles in starvation, cardiac remodeling, reverse remodeling, aging and inflammation to maintain cellular homeostasis in the heart. This review discusses some recent advances in understanding the basic molecular mechanisms underlying autophagosome and autolysosome formation and mitophagy and the roles of autophagy in cardiomyopathy. This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease".

KW - Autophagy

KW - Cardioprotection

KW - Inflammation

KW - Mitochondria

KW - Mitophagy

KW - Reverse remodeling

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JO - Journal of Molecular and Cellular Cardiology

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The role of autophagic degradation in the heart

Abstract

Keywords

UN SDGs

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