The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus

Michael P. Cancro, David P. D'Cruz, Munther A. Khamashta

Research output: Contribution to journalLiterature reviewpeer-review

225 Citations (Scopus)

Abstract

SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a soluble ligand of the TNF cytokine family, is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producting B cells. High levels of BLyS may relax B cell selection and contribute to autoantibody production, exacerbating the SLE disease state. This review discusses the mechanism of BLyS action on B cells, its role in SLE, and specific targeting of BLyS in the treatment of SLE.
Original languageEnglish
Pages (from-to)1066 - 1073
Number of pages8
JournalJournal of Clinical Investigation
Volume119
Issue number5
DOIs
Publication statusPublished - 1 May 2009

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