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The role of complement in the immunologic microenvironment of tumor cells: Potential therapeutic targets

Research output: Contribution to journalReview article

Kyeong Beom Jo, Alison Snape

Original languageEnglish
Pages (from-to)420-431
Number of pages12
JournalMicrobiology and Biotechnology Letters
Volume44
Issue number4
DOIs
Publication statusPublished - 1 Dec 2016

King's Authors

Abstract

The complement system comprises a set of essential molecules that bridge the innate and adaptive immune responses. Research has focused on how the complement system's destructive mechanism could potentially be harnessed for cancer treatment. However, cancer subverts the complement system to avoid immunosurveillance. In addition, a complement-triggered biological mechanism that contributes to cancer growth has been identified. Thus, drugs should be designed to homeostatically maintain a normal concentration of complement. This review explores three types of complement-related anti-cancer drugs: therapeutic antibodies, complement inhibitory drugs, and anti-complement regulatory drugs.

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