The Role of ErbB Receptors in Infection

Jemima Ho; David L. Moyes; Mahvash Tavassoli; Julian R. Naglik

doi:10.1016/j.tim.2017.04.009

The Role of ErbB Receptors in Infection

Jemima Ho, David L. Moyes, Mahvash Tavassoli, Julian R. Naglik

Centre for Host Microbiome Interactions

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

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Abstract

Members of the epidermal growth factor receptor family (ErbB family) possess a wide distribution and diverse functions ranging from cellular growth to migration and apoptosis. Though highly implicated in a variety of cancers, their involvement in infectious disease is less recognised. A growing body of evidence now highlights the importance of the ErbB family in a variety of infections. Their role as growth factor receptors, along with other characteristics, such as surface expression and continuous intracellular trafficking, make this receptor family ideally placed for exploitation by pathogens. Herein, we review our current understanding of the role of the ErbB family in the context of infectious disease, exploring the mechanisms that govern pathogen exploitation of this system.

Original language	English
Article number	29101209
Journal	Trends in Microbiology
Early online date	15 May 2017
DOIs	https://doi.org/10.1016/j.tim.2017.04.009
Publication status	Published - Nov 2017

Keywords

ErbB
EGFR
infection

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tim.2017.04.009

The Role of ErbB_HO_Accepted15May2017_GREEN AAMAccepted author manuscript, 761 KBLicence: CC BY-NC-ND

Cite this

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AB - Members of the epidermal growth factor receptor family (ErbB family) possess a wide distribution and diverse functions ranging from cellular growth to migration and apoptosis. Though highly implicated in a variety of cancers, their involvement in infectious disease is less recognised. A growing body of evidence now highlights the importance of the ErbB family in a variety of infections. Their role as growth factor receptors, along with other characteristics, such as surface expression and continuous intracellular trafficking, make this receptor family ideally placed for exploitation by pathogens. Herein, we review our current understanding of the role of the ErbB family in the context of infectious disease, exploring the mechanisms that govern pathogen exploitation of this system.

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The Role of ErbB Receptors in Infection

Abstract

Keywords

UN SDGs

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