The Role of Exosomes in Human Carcinogenesis and Cancer Therapy—Recent Findings from Molecular and Clinical Research

Katarzyna Stefańska; Małgorzata Józkowiak; Ana Angelova Volponi; Jamil Awad Shibli; Afsaneh Golkar-Narenji; Paweł Antosik; Dorota Bukowska; Hanna Piotrowska-Kempisty; Paul Mozdziak; Piotr Dzięgiel; Marzenna Podhorska-Okołów; Maciej Zabel; Marta Dyszkiewicz-Konwińska; Bartosz Kempisty

doi:10.3390/cells12030356

The Role of Exosomes in Human Carcinogenesis and Cancer Therapy—Recent Findings from Molecular and Clinical Research

Katarzyna Stefańska, Małgorzata Józkowiak, Ana Angelova Volponi, Jamil Awad Shibli, Afsaneh Golkar-Narenji, Paweł Antosik, Dorota Bukowska, Hanna Piotrowska-Kempisty, Paul Mozdziak, Piotr Dzięgiel, Marzenna Podhorska-Okołów, Maciej Zabel, Marta Dyszkiewicz-Konwińska, Bartosz Kempisty^*

^*Corresponding author for this work

Centre for Dental Education

Research output: Contribution to journal › Review article › peer-review

32 Citations (Scopus)

Abstract

Exosomes are biological nanoscale spherical lipid bilayer vesicles, 40–160 nm in diameter, produced by most mammalian cells in both physiological and pathological conditions. Exosomes are formed via the endosomal sorting complex required for transport (ESCRT). The primary function of exosomes is mediating cell-to-cell communication. In terms of cancer, exosomes play important roles as mediators of intercellular communication, leading to tumor progression. Moreover, they can serve as biomarkers for cancer detection and progression. Therefore, their utilization in cancer therapies has been suggested, either as drug delivery carriers or as a diagnostic tool. However, exosomes were also reported to be involved in cancer drug resistance via transferring information of drug resistance to sensitive cells. It is important to consider the current knowledge regarding the role of exosomes in cancer, drug resistance, cancer therapies, and their clinical application in cancer therapies.

Original language	English
Article number	356
Journal	Cells
Volume	12
Issue number	3
DOIs	https://doi.org/10.3390/cells12030356
Publication status	Published - Feb 2023

Keywords

cancer
cancer therapies
drug resistance
exosomes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cells12030356

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Stefańska, K., Józkowiak, M., Angelova Volponi, A., Shibli, J. A., Golkar-Narenji, A., Antosik, P., Bukowska, D., Piotrowska-Kempisty, H., Mozdziak, P., Dzięgiel, P., Podhorska-Okołów, M., Zabel, M., Dyszkiewicz-Konwińska, M., & Kempisty, B. (2023). The Role of Exosomes in Human Carcinogenesis and Cancer Therapy—Recent Findings from Molecular and Clinical Research. Cells, 12(3), Article 356. https://doi.org/10.3390/cells12030356

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title = "The Role of Exosomes in Human Carcinogenesis and Cancer Therapy—Recent Findings from Molecular and Clinical Research",

abstract = "Exosomes are biological nanoscale spherical lipid bilayer vesicles, 40–160 nm in diameter, produced by most mammalian cells in both physiological and pathological conditions. Exosomes are formed via the endosomal sorting complex required for transport (ESCRT). The primary function of exosomes is mediating cell-to-cell communication. In terms of cancer, exosomes play important roles as mediators of intercellular communication, leading to tumor progression. Moreover, they can serve as biomarkers for cancer detection and progression. Therefore, their utilization in cancer therapies has been suggested, either as drug delivery carriers or as a diagnostic tool. However, exosomes were also reported to be involved in cancer drug resistance via transferring information of drug resistance to sensitive cells. It is important to consider the current knowledge regarding the role of exosomes in cancer, drug resistance, cancer therapies, and their clinical application in cancer therapies.",

keywords = "cancer, cancer therapies, drug resistance, exosomes",

author = "Katarzyna Stefa{\'n}ska and Ma{\l}gorzata J{\'o}zkowiak and {Angelova Volponi}, Ana and Shibli, {Jamil Awad} and Afsaneh Golkar-Narenji and Pawe{\l} Antosik and Dorota Bukowska and Hanna Piotrowska-Kempisty and Paul Mozdziak and Piotr Dzi{\c e}giel and Marzenna Podhorska-Oko{\l}{\'o}w and Maciej Zabel and Marta Dyszkiewicz-Konwi{\'n}ska and Bartosz Kempisty",

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Stefańska, K, Józkowiak, M, Angelova Volponi, A, Shibli, JA, Golkar-Narenji, A, Antosik, P, Bukowska, D, Piotrowska-Kempisty, H, Mozdziak, P, Dzięgiel, P, Podhorska-Okołów, M, Zabel, M, Dyszkiewicz-Konwińska, M & Kempisty, B 2023, 'The Role of Exosomes in Human Carcinogenesis and Cancer Therapy—Recent Findings from Molecular and Clinical Research', Cells, vol. 12, no. 3, 356. https://doi.org/10.3390/cells12030356

TY - JOUR

T1 - The Role of Exosomes in Human Carcinogenesis and Cancer Therapy—Recent Findings from Molecular and Clinical Research

AU - Stefańska, Katarzyna

AU - Józkowiak, Małgorzata

AU - Angelova Volponi, Ana

AU - Shibli, Jamil Awad

AU - Golkar-Narenji, Afsaneh

AU - Antosik, Paweł

AU - Bukowska, Dorota

AU - Piotrowska-Kempisty, Hanna

AU - Mozdziak, Paul

AU - Dzięgiel, Piotr

AU - Podhorska-Okołów, Marzenna

AU - Zabel, Maciej

AU - Dyszkiewicz-Konwińska, Marta

AU - Kempisty, Bartosz

PY - 2023/2

Y1 - 2023/2

N2 - Exosomes are biological nanoscale spherical lipid bilayer vesicles, 40–160 nm in diameter, produced by most mammalian cells in both physiological and pathological conditions. Exosomes are formed via the endosomal sorting complex required for transport (ESCRT). The primary function of exosomes is mediating cell-to-cell communication. In terms of cancer, exosomes play important roles as mediators of intercellular communication, leading to tumor progression. Moreover, they can serve as biomarkers for cancer detection and progression. Therefore, their utilization in cancer therapies has been suggested, either as drug delivery carriers or as a diagnostic tool. However, exosomes were also reported to be involved in cancer drug resistance via transferring information of drug resistance to sensitive cells. It is important to consider the current knowledge regarding the role of exosomes in cancer, drug resistance, cancer therapies, and their clinical application in cancer therapies.

AB - Exosomes are biological nanoscale spherical lipid bilayer vesicles, 40–160 nm in diameter, produced by most mammalian cells in both physiological and pathological conditions. Exosomes are formed via the endosomal sorting complex required for transport (ESCRT). The primary function of exosomes is mediating cell-to-cell communication. In terms of cancer, exosomes play important roles as mediators of intercellular communication, leading to tumor progression. Moreover, they can serve as biomarkers for cancer detection and progression. Therefore, their utilization in cancer therapies has been suggested, either as drug delivery carriers or as a diagnostic tool. However, exosomes were also reported to be involved in cancer drug resistance via transferring information of drug resistance to sensitive cells. It is important to consider the current knowledge regarding the role of exosomes in cancer, drug resistance, cancer therapies, and their clinical application in cancer therapies.

KW - cancer

KW - cancer therapies

KW - drug resistance

KW - exosomes

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U2 - 10.3390/cells12030356

DO - 10.3390/cells12030356

M3 - Review article

C2 - 36766698

AN - SCOPUS:85147825392

SN - 2073-4409

VL - 12

JO - Cells

JF - Cells

IS - 3

M1 - 356

ER -

The Role of Exosomes in Human Carcinogenesis and Cancer Therapy—Recent Findings from Molecular and Clinical Research

Abstract

Keywords

UN SDGs

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