The role of glia in the spinal cord in neuropathic and inflammatory pain

Elizabeth Amy Old, Anna K. Clark, Marzia Malcangio*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

149 Citations (Scopus)

Abstract

Chronic pain, both inflammatory and neuropathic, is a debilitating condition in which the pain experience persists after the painful stimulus has resolved. The efficacy of current treatment strategies using opioids, NSAIDS and anticonvulsants is limited by the extensive side effects observed in patients, underlining the necessity for novel therapeutic targets. Preclinical models of chronic pain have recently provided evidence for a critical role played by glial cells in the mechanisms underlying the chronicity of pain, both at the site of damage in the periphery and in the dorsal horn of the spinal cord. Here microglia and astrocytes respond to the increased input from the periphery and change morphology, increase in number and release pro-nociceptive mediators such as ATP, cytokines and chemokines. These gliotransmitters can sensitise neurons by activation of their cognate receptors thereby contributing to central sensitization which is fundamental for the generation of allodynia, hyperalgesia and spontaneous pain.

Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
Pages145-170
Number of pages26
Volume227
DOIs
Publication statusPublished - Jan 2015

Keywords

  • Astrocytes
  • CX3CL1/R1
  • Glia
  • IL-1ä
  • Inflammatory pain
  • Microglia
  • Neuropathic pain
  • Rheumatoid arthritis
  • Spinal cord
  • TNF

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