The role of gsh in intracellular iron trafficking

Robert Hider*, Mayra Vera Aviles, Yu Lin Chen, Gladys Oluyemisi Latunde-Dada

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)

Abstract

Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in muscle, brain, and kidney physiology is far from established and evidence is presented that the iron(II)-binding capability of carnosine relates to this role.

Original languageEnglish
Article number1278
Pages (from-to)1-13
Number of pages13
JournalInternational Journal of Molecular Sciences
Volume22
Issue number3
DOIs
Publication statusPublished - 1 Feb 2021

Keywords

  • Carnosine
  • Cytosol
  • Glutathione
  • Histidine
  • Labile iron

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