The role of inflammatory cytokines as key modulators of neurogenesis

Alessandra Borsini; Patricia A Zunszain; Sandrine Thuret; Carmine M Pariante

doi:10.1016/j.tins.2014.12.006

The role of inflammatory cytokines as key modulators of neurogenesis

Alessandra Borsini, Patricia A Zunszain, Sandrine Thuret, Carmine M Pariante

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Abstract

Neurogenesis is an important process in the regulation of brain function and behaviour, highly active in early development and continuing throughout life. Recent studies have shown that neurogenesis is modulated by inflammatory cytokines in response to an activated immune system. To disentangle the effects of the different cytokines on neurogenesis, here we summarise and discuss in vitro studies on individual cytokines. We show that inflammatory cytokines have both a positive and negative role on proliferation and neuronal differentiation. Hence, this strengthens the notion that inflammation is involved in molecular and cellular mechanisms associated with complex cognitive processes and, therefore, that alterations in brain-immune communication are relevant to the development of neuropsychiatric disorders.

Original language	English
Pages (from-to)	145-157
Number of pages	13
Journal	Trends in Neurosciences
Volume	38
Issue number	3
Early online date	8 Jan 2015
DOIs	https://doi.org/10.1016/j.tins.2014.12.006
Publication status	Published - Mar 2015

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abstract = "Neurogenesis is an important process in the regulation of brain function and behaviour, highly active in early development and continuing throughout life. Recent studies have shown that neurogenesis is modulated by inflammatory cytokines in response to an activated immune system. To disentangle the effects of the different cytokines on neurogenesis, here we summarise and discuss in vitro studies on individual cytokines. We show that inflammatory cytokines have both a positive and negative role on proliferation and neuronal differentiation. Hence, this strengthens the notion that inflammation is involved in molecular and cellular mechanisms associated with complex cognitive processes and, therefore, that alterations in brain-immune communication are relevant to the development of neuropsychiatric disorders.",

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AU - Thuret, Sandrine

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AB - Neurogenesis is an important process in the regulation of brain function and behaviour, highly active in early development and continuing throughout life. Recent studies have shown that neurogenesis is modulated by inflammatory cytokines in response to an activated immune system. To disentangle the effects of the different cytokines on neurogenesis, here we summarise and discuss in vitro studies on individual cytokines. We show that inflammatory cytokines have both a positive and negative role on proliferation and neuronal differentiation. Hence, this strengthens the notion that inflammation is involved in molecular and cellular mechanisms associated with complex cognitive processes and, therefore, that alterations in brain-immune communication are relevant to the development of neuropsychiatric disorders.

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The role of inflammatory cytokines as key modulators of neurogenesis

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